ArticleJournal of natural products2011
Actinopolysporins A-C and tubercidin as a Pdcd4 stabilizer from the halophilic actinomycete Actinopolyspora erythraea YIM 90600.
Article in Journal of natural products, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Who cites it
24 citing papers in PubMed, 49 citations in OpenAlex.
- Defining the biomarkers in anti-MRSA fractions of soil Streptomycetes by multivariate analysis.Antonie van Leeuwenhoek · 2025Article
- Beyond traditional screening: Unveiling antibiotic potentials of actinomycetes in extreme environments.Heliyon · 2024Article
- Accessing the specialized metabolome of actinobacteria from the bulk soil of Paullinia cupana Mart. on the Brazilian Amazon: a promising source of bioactive compounds against soybean phytopathogens.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2024Article
- Bioprospecting of Actinobacterial Diversity and Antibacterial Secondary Metabolites from the Sediments of Four Saline Lakes on the Northern Tibetan Plateau.Microorganisms · 2023Article
- Comparative Analysis of the Placental Microbiome in Pregnancies with Late Fetal Growth Restriction versus Physiological Pregnancies.International journal of molecular sciences · 2023Article
- Rare HalophilicBioMed research international · 2023Article
- Linear polyketides produced by co-culture ofMarine life science & technology · 2022Article
- Sponge-associated spSaudi journal of biological sciences · 2021Article
- Halophiles and Their Biomolecules: Recent Advances and Future Applications in Biomedicine.Marine drugs · 2019Review
- Sampling Terrestrial Environments for Bacterial Polyketides.Molecules (Basel, Switzerland) · 2017Review
- New isofuranonaphthoquinones and isoindolequinones from Streptomyces sp. CB01883.The Journal of antibiotics · 2017Article
- Leveraging ecological theory to guide natural product discovery.Journal of industrial microbiology & biotechnology · 2016Review
- Article
- Angucyclines and Angucyclinones from Streptomyces sp. CB01913 Featuring C-Ring Cleavage and Expansion.Journal of natural products · 2015Article
- Tricyclic guanidine alkaloids from the marine sponge Acanthella cavernosa that stabilize the tumor suppressor PDCD4.Marine drugs · 2014Article
- Cryptocaryol Structure-Activity Relationship Study of Cancer Cell Cytotoxicity and Ability to Stabilize PDCD4.ACS medicinal chemistry letters · 2014Article
- Characterization of pomiferin triacetate as a novel mTOR and translation inhibitor.Biochemical pharmacology · 2014Article
- Biosynthetic potential-based strain prioritization for natural product discovery: a showcase for diterpenoid-producing actinomycetes.Journal of natural products · 2014Article
- Unexplored hypersaline habitats are sources of novel actinomycetes.Frontiers in microbiology · 2014Article
- Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 3 countries.
Funding
Abstract
Our current natural product program utilizes new actinomycetes originating from unexplored and underexplored ecological niches, employing cytotoxicity against a selected panel of cancer cell lines as the preliminary screen to identify hit strains for natural product dereplication, followed by mechanism-based assays of the purified natural products to discover potential anticancer drug leads. Three new linear polyketides, actinopolysporins A (1), B (2), and C (3), along with the known antineoplastic antibiotic tubercidin (4), were isolated from the halophilic actinomycete Actinopolyspora erythraea YIM 90600, and the structures of the new compounds were elucidated on the basis of spectroscopic data interpretation. All four compounds were assayed for their ability to stabilize the tumor suppressor programmed cell death protein 4 (Pdcd4), which is known to antagonize critical events in oncogenic pathways. Only 4 significantly inhibited proteasomal degradation of a model Pdcd4-luciferase fusion protein, with an IC50 of 0.88±0.09 μM, unveiling a novel biological activity for this well-studied natural product.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.