ArticleJournal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry2011
Characterization of MtnE, the fifth metallothionein member in Drosophila.
Article in Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 48 citations in OpenAlex.
- Acute exposure to mercury drives changes in gene expression in Drosophila melanogaster.BMC research notes · 2024Article
- Expression and Functional Analysis of the Metallothionein and Metal-Responsive Transcription Factor 1 inInternational journal of molecular sciences · 2024Article
- Prolonged Heat Stress during Winter Diapause Alters the Expression of Stress-Response Genes inInternational journal of molecular sciences · 2024Article
- Review
- Gawky modulates MTF-1-mediated transcription activation and metal discrimination.Nucleic acids research · 2021Article
- Essential (Mg, Fe, Zn and Cu) and Non-Essential (Cd and Pb) Elements in Predatory Insects (International journal of molecular sciences · 2020Article
- The evolution of insect metallothioneins.Proceedings. Biological sciences · 2020Article
- Anatomy and Physiology of the Digestive Tract ofGenetics · 2018Review
- Biogenesis of zinc storage granules inThe Journal of experimental biology · 2018Article
- Drosophila melanogaster Models of Metal-Related Human Diseases and Metal Toxicity.International journal of molecular sciences · 2017Review
- Article
- Natural and laboratory mutations in kuzbanian are associated with zinc stress phenotypes in Drosophila melanogaster.Scientific reports · 2017Article
- Functional studies of Drosophila zinc transporters reveal the mechanism for zinc excretion in Malpighian tubules.BMC biology · 2017Article
- Genetic Diversity in Insect Metal Tolerance.Frontiers in genetics · 2017Review
- Copper and Zinc Homeostasis: Lessons fromFrontiers in genetics · 2017Review
- Metallothioneins, unconventional proteins from unconventional animals: a long journey from nematodes to mammals.Biomolecules · 2014Review
- Two metallothionein genes in Oxya chinensis: molecular characteristics, expression patterns and roles in heavy metal stress.PloS one · 2014Article
- Iron absorption in Drosophila melanogaster.Nutrients · 2013Review
- A recessive X-linked mutation causes a threefold reduction of total body zinc accumulation in Drosophila melanogaster laboratory strains.FEBS open bio · 2013Article
- Efficient metal-specific transcription activation by Drosophila MTF-1 requires conserved cysteine residues in the carboxy-terminal domain.Biochimica et biophysica acta · 2012Article
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5 authors at 2 institutions in 2 countries.
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Abstract
Metallothioneins (MTs) constitute a family of cysteine-rich, low molecular weight metal-binding proteins which occur in almost all forms of life. They bind physiological metals, such as zinc and copper, as well as nonessential, toxic heavy metals, such as cadmium, mercury, and silver. MT expression is regulated at the transcriptional level by metal-regulatory transcription factor 1 (MTF-1), which binds to the metal-response elements (MREs) in the enhancer/promoter regions of MT genes. Drosophila was thought to have four MT genes, namely, MtnA, MtnB, MtnC, and MtnD. Here we characterize a new fifth member of Drosophila MT gene family, coding for metallothionein E (MtnE). The MtnE transcription unit is located head-to-head with the one of MtnD. The intervening sequence contains four MREs which bind, with different affinities, to MTF-1. Both of the divergently transcribed MT genes are completely dependent on MTF-1, whereby MtnE is consistently more strongly transcribed. MtnE expression is induced in response to heavy metals, notably copper, mercury, and silver, and is upregulated in a genetic background where the other four MTs are missing.
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