ArticleParasitology research2012
Blastocystis infection is associated with irritable bowel syndrome in a Mexican patient population.
Article in Parasitology research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers, 3 of them syntheses that pooled it.
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Who cites it
78 citing papers in PubMed, 3 syntheses or guidelines pooled it, 154 citations in OpenAlex.
- Prevalence and subtype distribution of Blastocystis infections among community participants in Thailand: a systematic review and meta-analysis.Parasite (Paris, France) · 2025Pooled it
- Epidemiology of Blastocystis sp. infection in China: a systematic review.Parasite (Paris, France) · 2019Pooled it
- The role of Blastocystis sp. and Dientamoeba fragilis in irritable bowel syndrome: a systematic review and meta-analysis.Parasitology research · 2017Pooled it
- Molecular Identification ofJournal of clinical medicine · 2025Article
- Parasite-mediated alteration of behaviour and biomolecular dynamics in a mouse model.Frontiers in cellular and infection microbiology · 2025Article
- Genetic Variation among the Partial Gene Sequences of the Ribosomal Protein Large-Two, the Internal Transcribed Spacer, and the Small Ribosomal Subunit ofMicroorganisms · 2024Article
- Irritable Bowel Syndrome Associated with Blastocystis hominis or Without Relationship to It? A Case-Control Study and Minireview.Acta parasitologica · 2024Review
- Differential gut microbiome in spondyloarthritis patients associated to Blastocystis colonization.Scientific reports · 2023Article
- Circulation and colonisation ofEpidemiology and infection · 2023Article
- Comparison of Various Diagnostic Techniques for the Detection ofJournal of veterinary research · 2023Article
- An update on the distribution ofHeliyon · 2022Article
- Higher amoebic and metronidazole resistant forms of Blastocystis sp. seen in schizophrenic patients.Parasites & vectors · 2022Article
- Modulation of microRNAs and claudin-7 in Caco-2 cell line treated with Blastocystis sp., subtype 3 soluble total antigen.BMC microbiology · 2022Article
- Influence ofJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2022Article
- Presence and significance of intestinal unicellular parasites in a morbidly obese population.International journal of obesity (2005) · 2022Article
- Exosomes secreted byFrontiers in medicine · 2022Article
- Molecular subtyping ofFrontiers in parasitology · 2022Article
- Occurrence, genetic diversity and zoonotic potential of Blastocystis sp. in forest musk deer (Moschus berezovskii) in Southwest China.Parasite (Paris, France) · 2022Article
- Gut Microbiota Shifting in Irritable Bowel Syndrome: The Mysterious Role ofFrontiers in medicine · 2022Review
- High occurrence ofGastroenterology and hepatology from bed to bench · 2022Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In recent times, some common "non-pathogenic" parasites, such as Blastocystis and Dientamoeba fragilis, have been associated to the aetiology of irritable bowel syndrome (IBS), while host pro-inflammatory cytokine gene polymorphisms might have a role in the pathophysiology of the disease. Therefore, Blastocystis subtypes (ST), D. fragilis and gene promoter single nucleotide polymorphisms of interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-α) in IBS patients and controls were studied. After giving written consent, 45 patients with symptoms of IBS according to the Rome III criteria and 45 controls were enrolled. DNA was extracted from peripheral blood for SNP analysis at position -174 for IL-6 as well as -238 and -308 for TNF-α. Blastocystis was more common in the IBS group (p = 0.043). Interestingly, D. fragilis was found more frequently in the control group (p = 0.002); Blastocystis ST1 and 3 were most frequent in both groups. Haploview analysis revealed linkage disequilibrium in TNF-α (p < 0.0001); however, none of the SNPs for IL-6 and TNF-α were found to be significantly related with IBS. The clinical and molecular approaches undertaken for the first time in Latin American IBS patients demonstrated an association with Blastocystis that supports a pathogenic role of this parasite in IBS Furthermore, co-infections with ST1 and ST3 were frequent; thus, the genetic diversity proposed within ST polymorphisms does not rule out that particular strains might be associated with disease. In addition, our results do not support a major contribution of IL-6 and TNF-α gene polymorphisms in the susceptibility to IBS.
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