ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2011
Effects of suppressing the DNA mismatch repair system on homeologous recombination in tomato.
Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 49 citations in OpenAlex.
- An overview of recent advances on wheat homologous and homoeologous recombination.Journal of experimental botany · 2026Review
- Accumulation ofFrontiers in plant science · 2025Article
- MSH7 confers quantitative variation in pollen fertility and boosts grain yield in maize.Plant biotechnology journal · 2024Article
- MSH2 stimulates interfering and inhibits non-interfering crossovers in response to genetic polymorphism.Nature communications · 2023Article
- Crossover patterning in plants.Plant reproduction · 2023Review
- Learning to tango with four (or more): the molecular basis of adaptation to polyploid meiosis.Plant reproduction · 2023Review
- If it ain't broke, don't fix it: evaluating the effect of increased recombination on response to selection for wheat breeding.G3 (Bethesda, Md.) · 2022Article
- Location and Identification on Chromosome 3B of Bread Wheat of Genes Affecting Chiasma Number.Plants (Basel, Switzerland) · 2022Article
- Meiosis in allopolyploid Arabidopsis suecica.The Plant journal : for cell and molecular biology · 2022Article
- Genomic prediction of the recombination rate variation in barley - A route to highly recombinogenic genotypes.Plant biotechnology journal · 2022Article
- The Obstacles and Potential Solution Clues of Prime Editing Applications in Tomato.Biodesign research · 2022Article
- Effective RNAi-Mediated Silencing of theGenes · 2021Article
- A major quantitative trait locus on chromosome A9, BnaPh1, controls homoeologous recombination in Brassica napus.The New phytologist · 2021Article
- Ph2 encodes the mismatch repair protein MSH7-3D that inhibits wheat homoeologous recombination.Nature communications · 2021Article
- MSH2 shapes the meiotic crossover landscape in relation to interhomolog polymorphism in Arabidopsis.The EMBO journal · 2020Article
- Structural Aspects of DNA Repair and Recombination in Crop Improvement.Frontiers in genetics · 2020Review
- Effects ofFrontiers in plant science · 2020Article
- Manipulation of crossover frequency and distribution for plant breeding.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2019Review
- New Phenotypes of Potato Co-induced by Mismatch Repair Deficiency and Somatic Hybridization.Frontiers in plant science · 2019Article
- New Possibilities on the Horizon: Genome Editing Makes the Whole Genome Accessible for Changes.Frontiers in plant science · 2019Review
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plant breeding, the ability to manipulate genetic (meiotic) recombination would be beneficial for facilitating gene transfer from wild relatives of crop plants. The DNA mismatch repair (MMR) system helps maintain genetic integrity by correcting base mismatches that arise via DNA synthesis or damage, and antagonizes recombination between homeologous (divergent) DNA sequences. Previous studies have established that the genomes of cultivated tomato (Solanum lycopersicum) and the wild relative S. lycopersicoides are substantially diverged (homeologous) such that recombination between their chromosomes is strongly reduced. Here, we report the effects on homeologous recombination of suppressing endogenous MMR genes in S. lycopersicum via RNAi-induced silencing of SlMSH2 and SlMSH7 or overexpressing dominant negatives of Arabidopsis MSH2 (AtMSH2-DN) in an alien substitution line (SL-8) of S. lycopersicoides in tomato. We show that certain inhibitions of MMR (RNAi of SlMSH7, AtMSH2-DN) are associated with modest increases in homeologous recombination, ranging from 3.8 to 29.2% (average rate of 17.8%) compared to controls. Unexpectedly, only the AtMSH2-DN proteins but not RNAi-induced silencing of MSH2 was found to increase homeologous recombination. The ratio of single to double crossovers (SCO:DCO ratio) decreased by approximately 50% in progeny of the AtMSH2-DN parents. An increase in the frequency of heterozygous SL-8 plants was also observed in the progeny of the SlMSH7-RNAi parents. Our findings may contribute to acceleration of introgression in cultivated tomato.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.