ArticleJournal of materials science. Materials in medicine2011
Antibacterial effect of 317L stainless steel contained copper in prevention of implant-related infection in vitro and in vivo.
Article in Journal of materials science. Materials in medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A systematic review of animal models for Staphylococcus aureus osteomyelitis.European cells & materials · 2014Pooled it
- Innovative antimicrobial coating of titanium implants with iodine.Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association · 2012Trial
- Cytotoxicity Assessment and Indentation Size Effect of Low-Cost Experimental Implant Alloys.ACS materials Au · 2026Article
- Copper-doped β-tricalcium phosphate: synthesis, characterization, andMaterials today. Bio · 2026Article
- Antimicrobial Activity and Characterization of a Validated Copper-Complexed Polymer Tape for Surface Disinfectant Applications.Antibiotics (Basel, Switzerland) · 2025Article
- Article
- Antimicrobial Composites Based on Methacrylic Acid-Methyl Methacrylate Electrospun Fibers Stabilized with Copper(II).Molecules (Basel, Switzerland) · 2024Article
- Dual-functional composite scaffolds for inhibiting infection and promoting bone regeneration.Materials today. Bio · 2022Review
- Application of Copper Nanoparticles in Dentistry.Nanomaterials (Basel, Switzerland) · 2022Review
- Osteoblastic Cell Responses of Copper Nanoparticle Coatings on Ti-6Al-7Nb Alloy Using Electrophoretic Deposition Method.BioMed research international · 2022Article
- Antibacterial metals and alloys for potential biomedical implants.Bioactive materials · 2021Review
- Biological applications of copper-containing materials.Bioactive materials · 2021Review
- Innovations in osteomyelitis research: A review of animal models.Animal models and experimental medicine · 2021Review
- Antibacterial and Antiviral Functional Materials: Chemistry and Biological Activity toward Tackling COVID-19-like Pandemics.ACS pharmacology & translational science · 2021Review
- Therapeutics and delivery vehicles for local treatment of osteomyelitis.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2020Review
- Article
- Characteristics of novel Ti-10Mo-xCu alloy by powder metallurgy for potential biomedical implant applications.Bioactive materials · 2020Article
- Time-Transient Effects of Silver and Copper in the Porous Titanium Dioxide Layer on Antibacterial Properties.Journal of functional biomaterials · 2020Article
- Preparation of antibacterial and osteoconductive 3D-printed PLGA/Cu(I)@ZIF-8 nanocomposite scaffolds for infected bone repair.Journal of nanobiotechnology · 2020Article
- An Antibacterial Strategy of Mg-Cu Bone Grafting in Infection-Mediated Periodontics.BioMed research international · 2020Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone and intramedullary bacterial infections are one of the most serious complications of the surgical repair of fractures. To reduce the incidence of implant-related infections, several biomaterial surface treatments with integrated antibiotics, antiseptics, or metal ions have been developed for implants. In this study, we evaluated the antibacterial activity and biocompatibility of 317L stainless steel containing 4.5% copper alloy (317L-Cu) in vitro and in vivo using an animal model. Common pathogens of implant-related infections are Staphylococcus aureus and Escherichia coli, which were injected into implant materials to study their antimicrobial potential. We compared antimicrobial potential of 317L-Cu with 317L stainless steel (317L) and titanium (Ti-6Al-4V) alloys as controls. Compared with controls, 317L-Cu materials inhibited colonization by both bacteria in vitro and in vivo. Compared with 317L and Ti-6Al-4V controls, 317L-Cu showed no significant difference in colony formation of osteoblast-like cells on metal surfaces after 72 h of incubation in vitro. Metal screws containing these materials were also made for our vivo study in a rabbit model. Tissue-implants were analyzed for infection and inflammatory changes by hematoxylin-eosin staining of implants in bone. The screw tract inflammation and infection of 317L-Cu was minimal, although some inflammatory cells gathered at acutely infected sites. In addition, after materials had been implanted for 14 days in vivo, the expression of insulin-like growth factor-1 (IGF-1) in osteoblasts around 317L-Cu screws tracts had increased compared with 317L and Ti-6Al-4V controls. Overall, 317L-Cu demonstrated strong antimicrobial activity and biocompatibility in vitro and in vivo and may be used as a biomaterial to reduce implant-related infections.
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Registered trials
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