Evidence map›Paper›PMID 21870060›Full record

ReviewCurrent atherosclerosis reports2011

Effects of dietary factors on lipoprotein-associated phospholipase A(2) (Lp-PLA (2)).

Cheuk-Kit Wong, Harvey D White

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Cheuk-Kit WongDunedin School of Medicine, University of Otago, Dunedin, New Zealand.
Harvey D White
Auckland City Hospital · NZUniversity of Otago · NZ

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipoprotein-associated phospholipase A(2) (Lp-PLA(2)) is an enzyme which binds to oxidized LDL and has a pro-inflammatory role in the pathogenesis of atherosclerosis. The Lp-PLA(2) Studies Collaboration showed the relationship between Lp-PLA(2) levels and activity with coronary heart disease and ischemic stroke. Levels and activity of Lp-PLA(2) are reduced by statins. There have been limited studies focused on dietary factors and effects on LpPLA(2). A recent article from the Nurses' Health Study (HNS) and the Health Professionals Follow-up Study (HPFS) has provided interesting insights. In this cross sectional study, a lower LpPLA(2) activity was found to be related to several dietary factors including higher percentage of energy consumed as protein instead of carbohydrate, mild to moderate intake of alcohol, higher mono-unsaturated fat intake instead of carbohydrate, and not being overweight. It is unknown whether changes in Lp-PLA(2) by diet alter cardiovascular risk.

Indexed as

Diet1-Alkyl-2-acetylglycerophosphocholine EsteraseAlcohol DrinkingAtherosclerosisDietary FatsDietary ProteinsHumansHydroxymethylglutaryl-CoA Reductase InhibitorsWeight Loss1-Alkyl-2-acetylglycerophosphocholine EsteraseDietary FatsDietary ProteinsHydroxymethylglutaryl-CoA Reductase Inhibitors

Identifiers

PMID21870060
OpenAlexW1992666128

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.