Evidence map›Paper›PMID 21869934›Full record

ArticleJournal of drug delivery2011

Nanocarriers for nitric oxide delivery.

Juliana Saraiva, Samantha S Marotta-Oliveira, Simone Aparecida Cicillini, Josimar de Oliveira Eloy, Juliana Maldonado Marchetti

Open access · hybridAbstract read
In one paragraph

Article in Journal of drug delivery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 65 citations in OpenAlex.

  1. Article
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  4. Review
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  7. Review
  8. Challenges and strategies forBioactive materials · 2021
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Review
  16. Nitric oxide-eluting nanocomposite for cardiovascular implants.Journal of materials science. Materials in medicine · 2014
    Article
  17. Nitric oxide and cancer: a review.World journal of surgical oncology · 2013
    Review
  18. Critical evaluation of biodegradable polymers used in nanodrugs.International journal of nanomedicine · 2013
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Juliana SaraivaFaculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14010-903 Ribeirão Preto, SP, Brazil.
Samantha S Marotta-Oliveira
Simone Aparecida Cicillini
Josimar de Oliveira Eloy
Juliana Maldonado Marchetti
Universidade de São Paulo · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitric oxide (NO) is a promising pharmaceutical agent that has vasodilative, antibacterial, and tumoricidal effects. To study the complex and wide-ranging roles of NO and to facilitate its therapeutic use, a great number of synthetic compounds (e.g., nitrosothiols, nitrosohydroxyamines, N-diazeniumdiolates, and nitrosyl metal complexes) have been developed to chemically stabilize and release NO in a controlled manner. Although NO is currently being exploited in many biomedical applications, its use is limited by several factors, including a short half-life, instability during storage, and potential toxicity. Additionally, efficient methods of both localized and systemic in vivo delivery and dose control are needed. One strategy for addressing these limitations and thus increasing the utility of NO donors is based on nanotechnology.

Identifiers

PMID21869934
PMCPMC3159988
OpenAlexW1972624254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.