ArticleJournal of oncology2011
Antigenic and Genotypic Similarity between Primary Glioblastomas and Their Derived Neurospheres.
Article in Journal of oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 28 citations in OpenAlex.
- RETRACTION: Stem Cell Niches in Glioblastoma: A Neuropathological View.BioMed research international · 2025Article
- Thermomagnetic Resonance Effect of the Extremely Low Frequency Electromagnetic Field on Three-Dimensional Cancer Models.International journal of molecular sciences · 2022Article
- Chondroitin Sulphate Proteoglycan 4 (NG2/CSPG4) Localization in Low- and High-Grade Gliomas.Cells · 2020Article
- SEL1L plays a major role in human malignant gliomas.The journal of pathology. Clinical research · 2020Article
- Levetiracetam enhances the temozolomide effect on glioblastoma stem cell proliferation and apoptosis.Cancer cell international · 2018Article
- Comparison among conventional and advanced MRI,Oncotarget · 2017Article
- Article
- Establishment and Biological Characterization of a Panel of Glioblastoma Multiforme (GBM) and GBM Variant Oncosphere Cell Lines.PloS one · 2016Article
- The Microenvironment in Gliomas: Phenotypic Expressions.Cancers · 2015Article
- SEL1L SNP rs12435998, a predictor of glioblastoma survival and response to radio-chemotherapy.Oncotarget · 2015Article
- The DNA damage/repair cascade in glioblastoma cell lines after chemotherapeutic agent treatment.International journal of oncology · 2015Article
- Astroblastoma: beside being a tumor entity, an occasional phenotype of astrocytic gliomas?OncoTargets and therapy · 2015Article
- Cells isolated from human glioblastoma multiforme express progesterone-induced blocking factor (PIBF).Cellular and molecular neurobiology · 2014Article
- Stem cell niches in glioblastoma: a neuropathological view.BioMed research international · 2014Article
- Temozolomide downregulates P-glycoprotein expression in glioblastoma stem cells by interfering with the Wnt3a/glycogen synthase-3 kinase/β-catenin pathway.Neuro-oncology · 2013Article
- Promoter hypermethylation of the EMP3 gene in a series of 229 human gliomas.BioMed research international · 2013Article
- MGMT promoter hypermethylation and its associations with genetic alterations in a series of 350 brain tumors.Journal of neuro-oncology · 2012Article
Corrections and comments
- Retracted
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Formation of neurospheres (NS) in cultures of glioblastomas (GBMs), with self-renewal, clonogenic capacities, and tumorigenicity following transplantation into immunodeficient mice, may denounce the existence of brain tumor stem cells (BTSCs) in vivo. In sixteen cell lines from resected primary glioblastomas, NS showed the same genetic alterations as primary tumors and the expression of stemness antigens. Adherent cells (AC), after adding 10% of fetal bovine serum (FBS) to the culture, were genetically different from NS and prevailingly expressed differentiation antigens. NS developed from a highly malignant tumor phenotype with proliferation, circumscribed necrosis, and high vessel density. Beside originating from transformed neural stem cells (NSCs), BTSCs may be contained within or correspond to dedifferentiated cells after mutation accumulation, which reacquire the expression of stemness antigens.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.