ArticleFrontiers in physiology2011
Mean field strategies induce unrealistic non-linearities in calcium puffs.
Article in Frontiers in physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed.
- Close agreement between deterministic versus stochastic modeling of first-passage time to vesicle fusion.Biophysical journal · 2022Article
- Termination of calcium puffs and coupled closings of inositol trisphosphate receptor channels.Cell calcium · 2014Article
- Frequency and relative prevalence of calcium blips and puffs in a model of small IP₃R clusters.Biophysical journal · 2014Article
- A stochastic model of calcium puffs based on single-channel data.Biophysical journal · 2013Article
- Intracellular calcium signals display an avalanche-like behavior over multiple lengthscales.Frontiers in physiology · 2012Article
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3 authors.
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Abstract
Mean field models are often useful approximations to biological systems, but sometimes, they can yield misleading results. In this work, we compare mean field approaches with stochastic models of intracellular calcium release. In particular, we concentrate on calcium signals generated by the concerted opening of several clustered channels (calcium puffs). To this end we simulate calcium puffs numerically and then try to reproduce features of the resulting calcium distribution using mean field models were all the channels open and close simultaneously. We show that an unrealistic non-linear relationship between the current and the number of open channels is needed to reproduce the simulated puffs. Furthermore, a single channel current which is five times smaller than the one of the stochastic simulations is also needed. Our study sheds light on the importance of the stochastic kinetics of the calcium release channel activity to estimate the release fluxes.
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