ArticleEMBO reports2011
Yan, an ETS-domain transcription factor, negatively modulates the Wingless pathway in the Drosophila eye.
Article in EMBO reports, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 41 citations in OpenAlex.
- Systematic generation ofFly · 2026Article
- Notch-hedgehog antagonism regulates stem cell niche formation through an E2-E3-E3 ubiquitin module.EMBO reports · 2026Article
- Adipocyte heterogeneity regulated by the Bithorax Complex-Wnt signaling crosstalk in Drosophila.EMBO reports · 2026Article
- Article
- Steroid hormone-induced wingless ligands tune female intestinal size in Drosophila.Nature communications · 2025Article
- Wnt/Wingless signaling promotes lipid mobilization through signal-induced transcriptional repression.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Canonical Wnt Signaling Promotes Formation of Somatic Permeability Barrier for Proper Germ Cell Differentiation.Frontiers in cell and developmental biology · 2022Article
- Dally-like protein sequesters multiple Wnt ligands in the Drosophila germarium.Developmental biology · 2020Article
- Dlp-mediated Hh and Wnt signaling interdependence is critical in the niche for germline stem cell progeny differentiation.Science advances · 2020Article
- Essential long-range action of Wingless/Wnt in adult intestinal compartmentalization.PLoS genetics · 2019Article
- RAL GTPases Drive Intestinal Stem Cell Function and Regeneration through Internalization of WNT Signalosomes.Cell stem cell · 2019Article
- A Context-Dependent Role for the RNF146 Ubiquitin Ligase in Wingless/Wnt Signaling inGenetics · 2019Article
- Reduced SERCA Function Preferentially Affects Wnt Signaling by Retaining E-Cadherin in the Endoplasmic Reticulum.Cell reports · 2019Article
- Article
- Article
- Wingless/Wnt Signaling in Intestinal Development, Homeostasis, Regeneration and Tumorigenesis: A Drosophila Perspective.Journal of developmental biology · 2018Review
- Wnt6 maintains anterior escort cells as an integral component of the germline stem cell niche.Development (Cambridge, England) · 2018Article
- A switch in the mode of Wnt signaling orchestrates the formation of germline stem cell differentiation niche in Drosophila.PLoS genetics · 2018Article
- Quantitative microscopy of the Drosophila ovary shows multiple niche signals specify progenitor cell fate.Nature communications · 2017Article
- Intestinal stem cell overproliferation resulting from inactivation of the APC tumor suppressor requires the transcription cofactors Earthbound and Erect wing.PLoS genetics · 2017Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We report the identification of yan, an ETS-domain transcription factor belonging to the Drosophila epidermal growth factor receptor (DER) pathway, as an antagonist of the Wingless signalling pathway. We demonstrate that cells lacking yan function in the Drosophila eye show increased Wingless pathway activity, and inhibition of Wingless signalling in yan(-/-) cells rescues the yan mutant phenotype. Biochemical analysis shows that Yan physically associates with Armadillo, a crucial effector of the Wingless pathway, thereby suggesting a direct regulatory mechanism. We conclude that yan represents a new and unsuspected molecular link between the Wingless and DER pathways.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.