Trial reportStroke2011
Increased frequency of first-episode poststroke depression after discontinuation of escitalopram.
Trial report in Stroke, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Prevention of depression in adults with long-term physical conditions.The Cochrane database of systematic reviews · 2021Pooled it
- Effectiveness of Problem-Solving Therapy in Improving Patient Mental Health, Function, Quality of Life, and Mortality Post-Stroke: A Systematic Review.Behavioral sciences (Basel, Switzerland) · 2024Review
- Preventive Approaches for Post-Stroke Depression: Where Do We Stand? A Systematic Review.Neuropsychiatric disease and treatment · 2021Review
- Developments in treating the nonmotor symptoms of stroke.Expert review of neurotherapeutics · 2020Review
- Treatment of Post-Stroke Depression.Current treatment options in neurology · 2019Review
- Association Between Anxiety, Depression, and Post-traumatic Stress Disorder and Outcomes After Ischemic Stroke.Frontiers in neurology · 2018Article
- Prevention of Mental Disorder in Older Adults: Recent Innovations and Future Directions.Generations (San Francisco, Calif.) · 2014Article
- PET imaging of serotoninergic neurotransmission with [(11)C]DASB and [(18)F]altanserin after focal cerebral ischemia in rats.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2013Article
- Depression in Late-Life: a Focus on Prevention.Focus (American Psychiatric Publishing) · 2013Article
- Exploring new frontiers in neuropsychopharmacology: SSRIs for stroke.Indian journal of psychiatry · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
background and purposeThe purpose of this study was to compare escitalopram, problem-solving therapy, and placebo to prevent poststroke depression during 6 months after discontinuation of treatment.
methodsWe examined for depression 33 patients assigned to placebo, 34 to escitalopram, and 41 to problem-solving therapy.
resultsAfter controlling for age, gender, prior mood disorder, and severity of stroke, new-onset major depression and Hamilton Depression scores were significantly higher 6 months after escitalopram was discontinued compared with the problem-solving therapy or placebo groups.
conclusionsDiscontinuation of escitalopram may increase poststroke depressive symptoms.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.