ArticleArteriosclerosis, thrombosis, and vascular biology2011
Gain and loss of function for glutathione synthesis: impact on advanced atherosclerosis in apolipoprotein E-deficient mice.
Article in Arteriosclerosis, thrombosis, and vascular biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Calcification in Vascular Smooth Muscle Cells Is Associated with Elevated GCLm and Impaired Contraction: Insights into Osteogenic Transdifferentiation and Therapeutic Approaches.Pathophysiology : the official journal of the International Society for Pathophysiology · 2025Article
- Dysregulated cellular metabolism in atherosclerosis: mediators and therapeutic opportunities.Nature metabolism · 2024Review
- Transaldolase inhibits CD36 expression by modulating glutathione-p38 signaling, exerting protective effects against macrophage foam cell formation.Acta biochimica et biophysica Sinica · 2023Article
- Cellular Compartmentalization, Glutathione Transport and Its Relevance in Some Pathologies.Antioxidants (Basel, Switzerland) · 2023Review
- Re-Visiting Antioxidant Therapy in Murine Advanced Atherosclerosis with Brussels Chicory, a Typical Vegetable in Mediterranean Diets.Nutrients · 2023Article
- Atherosclerosis preventive effects of marrubiin against (TNF-α)-induced oxidative stress and apoptosis.Journal of cardiovascular and thoracic research · 2023Article
- Induction of glutathione biosynthesis by glycine-based treatment mitigates atherosclerosis.Redox biology · 2022Article
- The Impact of Genetic Polymorphisms in Glutamate-Cysteine Ligase, a Key Enzyme of Glutathione Biosynthesis, on Ischemic Stroke Risk and Brain Infarct Size.Life (Basel, Switzerland) · 2022Article
- Identification of Crucial Genes and Pathways Associated with Atherosclerotic Plaque in Diabetic Patients.Pharmacogenomics and personalized medicine · 2021Article
- Targeting glutathione with the triterpenoid CDDO-Im protects against benzo-a-pyrene-1,6-quinone-induced cytotoxicity in endothelial cells.Molecular and cellular biochemistry · 2020Article
- Astaxanthin Treatment Induces Maturation and Functional Change of Myeloid-Derived Suppressor Cells in Tumor-Bearing Mice.Antioxidants (Basel, Switzerland) · 2020Article
- Glutathione "Redox Homeostasis" and Its Relation to Cardiovascular Disease.Oxidative medicine and cellular longevity · 2019Review
- Oxidative Stress and Inflammation, Key Targets of Atherosclerotic Plaque Progression and Vulnerability: Potential Impact of Physical Activity.Sports medicine (Auckland, N.Z.) · 2018Review
- Antioxidants in the Fight Against Atherosclerosis: Is This a Dead End?Current atherosclerosis reports · 2018Review
- Article
- Inhibition of Glutathione Production Induces Macrophage CD36 Expression and Enhances Cellular-oxidized Low Density Lipoprotein (oxLDL) Uptake.The Journal of biological chemistry · 2015Article
- Macrophages in vascular inflammation--From atherosclerosis to vasculitis.Autoimmunity · 2015Review
- S-glutathionylation in monocyte and macrophage (dys)function.International journal of molecular sciences · 2013Review
- Reactive oxygen species and thiol redox signaling in the macrophage biology of atherosclerosis.Antioxidants & redox signaling · 2012Review
- Heme oxygenase-1, oxidation, inflammation, and atherosclerosis.Frontiers in pharmacology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveGlutamate-cysteine ligase (GCL) is the rate-limiting step in glutathione synthesis. The enzyme is a heterodimer composed of a catalytic subunit, GCLC, and a modifier subunit, GCLM. We generated apolipoprotein E (apoE)-/- mice deficient in GCLM (apoE-/-/Gclm-/-) and transgenic mice that overexpress GCLC specifically in macrophages (apoE-/-/Gclc-Tg) to test the hypothesis that significantly altering the availability of glutathione has a measurable impact on both the initiation and progression of atherosclerosis. METHODS AND
resultsAtherosclerotic plaque size and composition were measured in the innominate artery in chow-fed male and female mice at 20, 30, 40, and 50 weeks of age and in the aortic sinus at 40 and 50 weeks of age. The apoE-/-/Gclm-/- mice more rapidly developed complex lesions, whereas the apoE-/-/Gclc-Tg mice had reduced lesion development compared with the littermate apoE-/- control mice. Transplantation of bone marrow from the apoE-/-/Gclm-/- and apoE-/-/Gclc-Tg mice into apoE-/- mice with established lesions also stimulated or inhibited further lesion development at 30 weeks posttransplant.
conclusionGain and loss of function in the capacity to synthesize glutathione especially in macrophages has reciprocal effects on the initiation and progression of atherosclerosis at multiple sites in apoE-/- mice.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.