ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Effect of old age on human skeletal muscle force-velocity and fatigue properties.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
57 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Post-fatigue recovery of power, postural control and physical function in older women.PloS one · 2017Trial
- Neuromuscular fatigue in young and older men using constant or variable resistance.European journal of applied physiology · 2013Trial
- Cellular signaling within aged skeletal muscle reveals a dysregulated stress-induced remodeling response following volumetric muscle loss in female mice.Physiological reports · 2026Article
- Sex-specific effects of fatiguing exercise on skeletal muscle passive mechanics are preserved in aging.bioRxiv : the preprint server for biology · 2026Article
- Initial contractions of a single-load fatiguing exercise provide a valid assessment of age-related differences in peak power.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
- Effects of acidosis and inorganic phosphate on CaAmerican journal of physiology. Cell physiology · 2026Article
- Non-local Muscle Fatigue in Young and Middle-Aged Women following Fast-Paced Walking.International journal of exercise science · 2026Article
- Article
- Motor performance and aging in males and females.Journal of electromyography and kinesiology : official journal of the International Society of Electrophysiological Kinesiology · 2025Review
- The effects of hip abductor fatigue on gait instability in older adults.Journal of neurophysiology · 2025Article
- Development and Assessment of a Soft Wearable for sEMG-Based Hand Grip Detection and Control of a Virtual Environment.Sensors (Basel, Switzerland) · 2025Article
- Cellular and molecular contractile function in aged human skeletal muscle is altered by phosphate and acidosis and partially reversed with an ATP analog.American journal of physiology. Cell physiology · 2025Article
- Has Muscle Power Better Discriminative Capacity Compared to Muscle Strength in Predicting Worsening Disability in Older Adults?The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Cumulative effects of HThe Journal of physiology · 2025Article
- Neural and muscular contributions to the age-related differences in peak power of the knee extensors in men and women.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- Single-session measures of quadriceps neuromuscular function are reliable in healthy females and unaffected by age.European journal of applied physiology · 2024Article
- Neural and muscular contributions to the age-related loss in power of the knee extensors in men and women.bioRxiv : the preprint server for biology · 2023Article
- Ten-year longitudinal changes in muscle power, force, and velocity in young, middle-aged, and older adults.Journal of cachexia, sarcopenia and muscle · 2023Article
- Age-related changes in gait biomechanics and their impact on the metabolic cost of walking: Report from a National Institute on Aging workshop.Experimental gerontology · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
It is generally accepted that the muscles of aged individuals contract with less force, have slower relaxation rates, and demonstrate a downward shift in their force-velocity relationship. The factors mediating age-related differences in skeletal muscle fatigue are less clear. The present study was designed to test the hypothesis that age-related shifts in the force-velocity relationship impact the fatigue response in a velocity-dependent manner. Three fatigue protocols, consisting of intermittent, maximum voluntary knee extension contractions performed for 4 min, were performed by 11 young (23.5 ± 0.9 yr, mean ± SE) and 10 older (68.9 ± 4.3) women. The older group fatigued less during isometric contractions than the young group (to 71.1 ± 3.7% initial torque and 59.8 ± 2.5%, respectively; P = 0.02), while the opposite was true during contractions performed at a relatively high angular velocity of 270°·s(-1) (old: 28.0 ± 3.9% initial power, young: 52.1 ± 6.9%; P < 0.01). Fatigue was not different (P = 0.74) between groups during contractions at an intermediate velocity, which was selected for each participant based on their force-velocity relationship. There was a significant association between force-velocity properties and fatigue induced by the intermediate-velocity fatigue protocol in the older (r = 0.72; P = 0.02) and young (r = 0.63; P = 0.04) groups. These results indicate that contractile velocity has a profound impact on age-related skeletal muscle fatigue resistance and suggest that changes in the force-velocity relationship partially mediate this effect.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.