ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Pharmacological curve fitting to analyze cutaneous adrenergic responses.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- Peripheral Microvascular Vasodilatory Response to Estradiol and Genistein in Women with Insulin Resistance.Microcirculation (New York, N.Y. : 1994) · 2015Trial
- Comparing cutaneous NO-dependent vasodilation between young males and females.medRxiv : the preprint server for health sciences · 2026Article
- The TWW Growth Model and Its Application in the Analysis of Quantitative Polymerase Chain Reaction.Bioinformatics and biology insights · 2024Article
- Healthy active older adults have enhanced KAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Local angiotensin-(1-7) administration improves microvascular endothelial function in women who have had preeclampsia.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Vascular αAmerican journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Microphysiological flux balance platform unravels the dynamics of drug induced steatosis.Lab on a chip · 2018Article
- Endothelial function is impaired in the cutaneous microcirculation of adults with psoriasis through reductions in nitric oxide-dependent vasodilation.American journal of physiology. Heart and circulatory physiology · 2018Article
- Alterations in endothelin type B receptor contribute to microvascular dysfunction in women who have had preeclampsia.Clinical science (London, England : 1979) · 2017Article
- Increased Angiotensin II Sensitivity Contributes to Microvascular Dysfunction in Women Who Have Had Preeclampsia.Hypertension (Dallas, Tex. : 1979) · 2017Article
- Neurovascular mechanisms underlying augmented cold-induced reflex cutaneous vasoconstriction in human hypertension.The Journal of physiology · 2017Article
- Intradermal administration of atrial natriuretic peptide has no effect on sweating and cutaneous vasodilator responses in young male adults.Temperature (Austin, Tex.) · 2017Article
- Cutaneous blood flow during intradermal NO administration in young and older adults: roles for calcium-activated potassium channels and cyclooxygenase?American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- Intradermal administration of ATP augments methacholine-induced cutaneous vasodilation but not sweating in young males and females.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Article
- An automated fitting procedure and software for dose-response curves with multiphasic features.Scientific reports · 2015Article
- Sympathetic control of reflex cutaneous vasoconstriction in human aging.Journal of applied physiology (Bethesda, Md. : 1985) · 2015Review
- Evidence for a functional vasodilatatory role for hydrogen sulphide in the human cutaneous microvasculature.The Journal of physiology · 2015Article
- Impaired increases in skin sympathetic nerve activity contribute to age-related decrements in reflex cutaneous vasoconstriction.The Journal of physiology · 2015Article
- Lack of limb or sex differences in the cutaneous vascular responses to exogenous norepinephrine.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Androgens influence microvascular dilation in PCOS through ET-A and ET-B receptors.American journal of physiology. Endocrinology and metabolism · 2013Article
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Authors and funding
4 authors.
Funding
Abstract
Although dose-response curves are commonly used to describe in vivo cutaneous α-adrenergic responses, modeling parameters and analyses methods are not consistent across studies. The goal of the present investigation was to compare three analysis methods for in vivo cutaneous vasoconstriction studies using one reference data set. Eight women (22 ± 1 yr, 24 ± 1 kg/m(2)) were instrumented with three cutaneous microdialysis probes for progressive norepinephrine (NE) infusions (1 × 10(-8), 1 × 10(-6), 1 × 10(-5), 1 × 10(-4), and 1 × 10(-3) logM). NE was infused alone, co-infused with NG-monomethyl-l-arginine (l-NMMA, 10 mM) or Ketorolac tromethamine (KETO, 10 mM). For each probe, dose-response curves were generated using three commonly reported analyses methods: 1) nonlinear modeling without data manipulation, 2) nonlinear modeling with data normalization and constraints, and 3) percent change from baseline without modeling. Not all data conformed to sigmoidal dose-response curves using analysis 1, whereas all subjects' curves were modeled using analysis 2. When analyzing only curves that fit the sigmoidal model, NE + KETO induced a leftward shift in ED(50) compared with NE alone with analyses 1 and 2 (F test, P < 0.05) but only tended to shift the response leftward with analysis 3 (repeated-measures ANOVA, P = 0.08). Neither maximal vasoconstrictor capacity (E(max)) in analysis 1 nor %change CVC change from baseline in analysis 3 were altered by blocking agents. In conclusion, although the overall detection of curve shifts and interpretation was similar between the two modeling methods of curve fitting, analysis 2 produced more sigmoidal curves.
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