ArticleAJNR. American journal of neuroradiology
Carotid plaque enhancement and symptom correlations: an evaluation by using multidetector row CT angiography.
Article in AJNR. American journal of neuroradiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Carotid Artery Wall Imaging: Perspective and Guidelines from the ASNR Vessel Wall Imaging Study Group and Expert Consensus Recommendations of the American Society of Neuroradiology.AJNR. American journal of neuroradiology · 2018Guideline
- Correlation between fissured fibrous cap and contrast enhancement: preliminary results with the use of CTA and histologic validation.AJNR. American journal of neuroradiology · 2014Trial
- Imaging Predictors of Silent Brain Lesions: Correlating Carotid Plaque Features on Ultrasound and CT in an Observational Study.Journal of clinical medicine · 2026Article
- Assessment of Attenuation in Pericarotid Fat among Patients with Carotid Plaque and Spontaneous Carotid Dissection.AJNR. American journal of neuroradiology · 2025Article
- High-risk coronary plaque of sudden cardiac death victims: postmortem CT angiographic features and histopathologic findings.International journal of legal medicine · 2024Article
- Coronary CT angiography for the assessment of atherosclerotic plaque inflammation: postmortem proof of concept with histological validation.European radiology · 2024Article
- Novel Imaging-Based Biomarkers for Identifying Carotid Plaque Vulnerability.Biomolecules · 2023Review
- CT Marker in Emergency Imaging of Acute Basilar Artery Occlusion: Thrombosis vs. Embolism.Diagnostics (Basel, Switzerland) · 2022Article
- Imaging Approaches to the Diagnosis of Vascular Diseases.Current atherosclerosis reports · 2022Review
- Review of imaging biomarkers for the vulnerable carotid plaque.JVS-vascular science · 2021Review
- Perivascular Fat Density and Contrast Plaque Enhancement: Does a Correlation Exist?AJNR. American journal of neuroradiology · 2020Article
- CT-pathologic correlation of non-calcified atherosclerotic arterial plaques: a study using carotid endarterectomy specimens.The British journal of radiology · 2020Article
- CT Attenuation Analysis of Carotid Intraplaque Hemorrhage.AJNR. American journal of neuroradiology · 2018Article
- Multi-modal CT scanning in the evaluation of cerebrovascular disease patients.Cardiovascular diagnosis and therapy · 2014Review
- Carotid artery plaque characterization using CT multienergy imaging.AJNR. American journal of neuroradiology · 2013Article
- Association between carotid artery plaque type and cerebral microbleeds.AJNR. American journal of neuroradiology · 2012Article
- Association between carotid plaque enhancement shown by multidetector CT angiography and histologically validated microvessel density.European radiology · 2012Article
- Carotid artery plaque classification: does contrast enhancement play a significant role?AJNR. American journal of neuroradiology · 2012Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
background and purposeThe identification of plaque characteristics that determine its vulnerability is extremely important. The purpose of this work was to evaluate CPE after administration of contrast material and to assess whether there is a statistical association between CPE and cerebrovascular symptoms. MATERIALS AND
methodsNinety-seven consecutive patients (69 men, 28 women; mean age, 62 years; age range, 39-82 years), studied by using an MDCT scanner, were retrospectively analyzed. Examinations were performed before and after administration of contrast medium. Plaque enhancement was analyzed, and the obtained data were compared with the patient's symptoms. Patients were classified as symptomatic (TIA or stroke with a temporal window of 6 months) or asymptomatic according to neurologic assessment and the TOAST criteria. The ROC curve and Az were calculated, and multiple logistic regression analysis was performed.
resultsThirty-nine patients were excluded because they had calcified plaques (40.2%). CPE was observed in 74% of the remaining 58 patients. A statistically significant difference was observed between symptomatic and asymptomatic patients for the presence of CPE (P = .0013; OR = 7.5). Moreover, we observed that CPE was higher in fatty plaques (P = .035) than in mixed ones and more frequent in the former (P = .0119). The ROC curve demonstrated that a threshold of 15 HU is associated with a specificity and sensitivity of 83.33% and 76.47%, respectively. Multiple logistic regression showed that CPE and symptoms are associated (P = .0315).
conclusionsThe results of our study suggest that for noncalcified carotid plaques, the presence of CPE is associated with cerebrovascular symptoms. Fatty plaques are more likely to have CPE compared with mixed plaques.
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