ArticleGenetics2011
Cell architecture: surrounding muscle cells shape gland cell morphology in the Caenorhabditis elegans pharynx.
Article in Genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- From muscle to gland: The reorganization of the terminal bulb within the symbiotic Stilbonematinae (Nematoda, Desmodoroidea).Journal of nematology · 2026Article
- Distinct mechanoreceptor pezo-1 isoforms modulate food intake in the nematode Caenorhabditis elegans.G3 (Bethesda, Md.) · 2022Article
- Repulsive guidance molecule acts in axon branching in Caenorhabditis elegans.Scientific reports · 2021Article
- A 4D single-cell protein atlas of transcription factors delineates spatiotemporal patterning during embryogenesis.Nature methods · 2021Article
- Subcellular three-dimensional imaging deep through multicellular thick samples by structured illumination microscopy and adaptive optics.Nature communications · 2021Article
- CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.PLoS biology · 2019Article
- Evolutionarily conserved TRH neuropeptide pathway regulates growth inProceedings of the National Academy of Sciences of the United States of America · 2017Article
- TGF-β signaling can act from multiple tissues to regulate C. elegans body size.BMC developmental biology · 2014Article
- CEH-28 activates dbl-1 expression and TGF-β signaling in the C. elegans M4 neuron.Developmental biology · 2014Article
- Cell interactions and patterned intercalations shape and link epithelial tubes in C. elegans.PLoS genetics · 2013Article
- Laminin is required to orient epithelial polarity in the C. elegans pharynx.Development (Cambridge, England) · 2012Article
- Developmental genetics of the Caenorhabditis elegans pharynx.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
5 authors.
Funding
Abstract
The acquisition and maintenance of shape is critical for the normal function of most cells. Here we investigate the morphology of the pharyngeal glands of Caenorhabditis elegans. These unicellular glands have long cellular processes that extend discrete lengths through the pharyngeal musculature and terminate at ducts connected to the pharyngeal lumen. From a genetic screen we identified several mutants that affect pharyngeal gland morphology. The most severe such mutant is an allele of sma-1, which encodes a β-spectrin required for embryonic elongation, including elongation of the pharynx. In sma-1 mutants, gland projections form normally but become increasingly abnormal over time, acquiring additional branches, outgrowths, and swelling, suggestive of hypertrophy. Rather than acting in pharyngeal glands, sma-1 functions in the surrounding musculature, suggesting that pharyngeal muscles play a critical role in maintenance of gland morphology by restricting their growth, and analysis of other mutants known to affect pharyngeal muscles supports this hypothesis. We suggest that gland morphology is maintained by a balance of forces from the muscles and the glands.
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