Evidence map›Paper›PMID 21868592›Full record

ArticleClinical pediatrics2012

Detours on the road to diagnosis of Graves disease.

Emily K Sims, Erica A Eugster, Todd D Nebesio

Abstract readEvaluation Study
In one paragraph

Article in Clinical pediatrics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Emily K SimsRiley Hospital for Children, Indianapolis, IN 46202, USA. eksims@iupui.edu
Erica A Eugster
Todd D Nebesio

Funding

Endocrine Scientist Training ProgramT32DK065549 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI EUGSTER, ERICA A · 2005 to 2019
$2.4M
NIDDK NIH HHS T32 DK065549
6 · The paper itself

Abstract

objectivesThe aims of this study were to determine the frequency at which spurious diagnoses and unnecessary treatment occurs prior to the diagnosis of Graves disease (GD) and to evaluate the economic consequences of these events.

methodsRetrospective chart review of children diagnosed with GD.

resultsA total of 76 children (61 girls) aged 11.9 ± 3.8 years were identified. In all, 17 (22.4%) were referred to other subspecialists prior to diagnosis of GD. Six were hospitalized, and 2 visited emergency rooms. A total of 15 (19.7%) underwent nonthyroid-related studies. Estimated cost of testing and procedures ranged from $49 to $14,000. Twelve (15.8%) were diagnosed with attention deficit/hyperactivity disorder, and 16 (21.1%) were started on medications for other conditions prior to diagnosis of GD.

conclusionsEvaluation and treatment for presumed other disorders are common in children with GD. A high index of suspicion for hyperthyroidism by primary care providers may help to avoid clinical detours that may be costly and delay diagnosis.

Indexed as

AdolescentChildChild, PreschoolDelayed DiagnosisDiagnosis, DifferentialDiagnostic ErrorsFemaleGraves DiseaseHealth Care CostsHumansIndianaMaleRetrospective Studies

Identifiers

PMID21868592
PMCPMC4094030

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.