ArticleJournal of cell science2011
A new regulatory function of the region proximal to the RGG box in the fragile X mental retardation protein.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- RNA-binding FMRP and Staufen sequentially regulate the Coracle scaffold to control synaptic glutamate receptor and bouton development.Development (Cambridge, England) · 2022Article
- Aberrant Phase Transitions: Side Effects and Novel Therapeutic Strategies in Human Disease.Frontiers in genetics · 2019Review
- Arginine methylation of the C-terminus RGG motif promotes TOP3B topoisomerase activity and stress granule localization.Nucleic acids research · 2018Article
- Altered expression of the FMR1 splicing variants landscape in premutation carriers.Biochimica et biophysica acta. Gene regulatory mechanisms · 2017Article
- The new (dis)order in RNA regulation.Cell communication and signaling : CCS · 2016Review
- Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins.Biochimie · 2015Review
- Arginine methylation of RNA-binding proteins regulates cell function and differentiation.Molecular reproduction and development · 2012Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Fragile X mental retardation protein (FMRP) is required for normal cognition. FMRP has two autosomal paralogs, which although similar to FMRP, cannot compensate for the loss of FMRP expression in brain. The arginine- and glycine-rich region of FMRP (the RGG box) is unique; it is the high-affinity RNA-binding motif in FMRP and is encoded by exon 15. Alternative splicing occurs in the 5' end of exon 15, which is predicted to affect the structure of the distally encoded RGG box. Here, we provide evidence that isoform 3, which removes 25 amino acids from the 5' end of exon 15, has an altered conformation that reduces binding of a specific antibody and renders the RGG box unable to efficiently associate with polyribosomes. Isoform 3 is also compromised in its ability to form granules and to associate with a key messenger ribonucleoprotein Yb1 (also known as p50, NSEP1 and YBX1). Significantly, these functions are similarly compromised when the RGG box is absent from FMRP, suggesting an important regulatory role of the N-terminal region encoded by exon 15.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.