ArticleScience signaling2011
Yeast dynamically modify their environment to achieve better mating efficiency.
Article in Science signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed.
- Optogenetic control of pheromone gradients and mating behavior in budding yeast.Life science alliance · 2025Article
- Design patterns of biological cells.BioEssays : news and reviews in molecular, cellular and developmental biology · 2024Review
- Characterizing the Impact of Communication on Cellular and Collective Behavior Using a Three-Dimensional Multiscale Cellular Model.Entropy (Basel, Switzerland) · 2023Article
- Coupling Cell Communication and Optogenetics: Implementation of a Light-Inducible Intercellular System in Yeast.ACS synthetic biology · 2023Article
- Determination of the Mating Efficiency of Haploids in Saccharomyces cerevisiae.Journal of visualized experiments : JoVE · 2022Article
- Mechanism of commitment to a mating partner inMolecular biology of the cell · 2022Article
- Pheromone Guidance of Polarity Site Movement in Yeast.Biomolecules · 2022Article
- A novel stochastic simulation approach enables exploration of mechanisms for regulating polarity site movement.PLoS computational biology · 2021Article
- Exploratory polarization facilitates mating partner selection inMolecular biology of the cell · 2021Article
- Dominance of Mating Type A1 and Indication of Epigenetic Effects During Early Stages of Mating inFrontiers in microbiology · 2020Article
- Unisexual reproduction promotes competition for mating partners in the global human fungal pathogen Cryptococcus deneoformans.PLoS genetics · 2019Article
- Quantitative analysis of the yeast pheromone pathway.Yeast (Chichester, England) · 2019Article
- Late-Arriving Signals Contribute Less to Cell-Fate Decisions.Biophysical journal · 2017Article
- A modeling study of budding yeast colony formation and its relationship to budding pattern and aging.PLoS computational biology · 2017Article
- Testing the limits of gradient sensing.PLoS computational biology · 2017Article
- Spatial and temporal signal processing and decision making by MAPK pathways.The Journal of cell biology · 2017Review
- Single-cell dynamics and variability of MAPK activity in a yeast differentiation pathway.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Sensory input attenuation allows predictive sexual response in yeast.Nature communications · 2016Article
- Modelling of Yeast Mating Reveals Robustness Strategies for Cell-Cell Interactions.PLoS computational biology · 2016Article
- Hydrophobin-Based Surface Engineering for Sensitive and Robust Quantification of Yeast Pheromones.Sensors (Basel, Switzerland) · 2016Article
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Authors and funding
8 authors.
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Abstract
The maintenance and detection of signaling gradients are critical for proper development and cell migration. In single-cell organisms, gradient detection allows cells to orient toward a distant mating partner or nutrient source. Budding yeast expand their growth toward mating pheromone gradients through a process known as chemotropic growth. MATα cells secrete α-factor pheromone that stimulates chemotropism and mating differentiation in MATa cells and vice versa. Paradoxically, MATa cells secrete Bar1, a protease that degrades α-factor and that attenuates the mating response, yet is also required for efficient mating. We observed that MATa cells avoid each other during chemotropic growth. To explore this behavior, we developed a computational platform to simulate chemotropic growth. Our simulations indicated that the release of Bar1 enabled individual MATa cells to act as α-factor sinks. The simulations suggested that the resultant local reshaping of pheromone concentration created gradients that were directed away from neighboring MATa cells (self-avoidance) and that were increasingly amplified toward partners of the opposite sex during elongation. The behavior of Bar1-deficient cells in gradient chambers and mating assays supported these predictions from the simulations. Thus, budding yeast dynamically remodel their environment to ensure productive responses to an external stimulus and avoid nonproductive cell-cell interactions.
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