ArticleScience signaling2011
K2P potassium channels, mysterious and paradoxically exciting.
Article in Science signaling, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- TWIK-1 plays distinct roles in spinal and peripheral sensory circuits controlling mechanical sensitivity and neuropathic hypersensitivity.Signal transduction and targeted therapy · 2026Article
- The effects of doxapram and its potential interactions with K2P channels in experimental model preparations.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Fluorescence Fluctuation Spectroscopy enables quantification of potassium channel subunit dynamics and stoichiometry.Scientific reports · 2021Article
- Selectivity filter instability dominates the low intrinsic activity of the TWIK-1 K2P KThe Journal of biological chemistry · 2020Article
- Bunyavirus requirement for endosomal K+ reveals new roles of cellular ion channels during infection.PLoS pathogens · 2018Article
- Kir2.1 and K2P1 channels reconstitute two levels of resting membrane potential in cardiomyocytes.The Journal of physiology · 2017Article
- Modulation of Potassium Channels Inhibits Bunyavirus Infection.The Journal of biological chemistry · 2016Article
- K₂p channels in plants and animals.Pflugers Archiv : European journal of physiology · 2015Review
- Molecular aspects of structure, gating, and physiology of pH-sensitive background K2P and Kir K+-transport channels.Physiological reviews · 2015Review
- A hydrophobic barrier deep within the inner pore of the TWIK-1 K2P potassium channel.Nature communications · 2014Article
- SUMOylation silences heterodimeric TASK potassium channels containing K2P1 subunits in cerebellar granule neurons.Science signaling · 2012Article
- Acid-sensitive TWIK and TASK two-pore domain potassium channels change ion selectivity and become permeable to sodium in extracellular acidification.The Journal of biological chemistry · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
New evidence reveals that the common electrolyte disorder hypokalemia can induce K2P1 channels that are normally selective for K+ to break the rules and conduct Na+. This defiant behavior leads to paradoxical depolarization of many cells in the heart, increasing the risk for lethal arrhythmia. The new research resolves a mystery uncovered 50 years ago and bestows an array of new riddles. Here, I discuss how K2P1 might achieve this alchemy--through stable residence of the K+ selectivity filter in a Na+-conductive state between its open and C-inactive configurations--and predict that other K+ channels and environmental stimuli will be discovered to produce the same excitatory misconduct.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.