ArticleUrology2011
The effects of acute and chronic psychological stress on bladder function in a rodent model.
Article in Urology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers.
What it found
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Who cites it
67 citing papers in PubMed, 110 citations in OpenAlex.
- Effects of Oxytocin on Rats With Stress-Induced Increased Urinary Frequency.International neurourology journal · 2026Article
- Effects of Water Avoidance Stress as a Psychological Stress Model and Coenzyme Q10 on Reproductive, Endocrine, and Ovarian Responses in Adult Female Rats.Animals : an open access journal from MDPI · 2026Article
- The Role of TRPV4 in Repeated Variate Stress-Induced Increases in Voiding Frequency and Somatic Sensitivity in Male and Female Mice.Journal of molecular neuroscience : MN · 2026Article
- Oral administration of kratom leaf extract alleviates anxiety-like behavior, urinary bladder pain, voiding dysfunction, and bladder hypercontractility via attenuating muscarinic receptor response in male mice exposed to chronic water avoidance stress.Frontiers in neuroscience · 2026Article
- Odor-specific olfactory stimulation is associated with selective transcriptional changes and partial improvement of stress-evoked bladder overactivity in mice.Frontiers in neuroscience · 2026Article
- Overactive bladder phenotype induced by chronic activation of hypothalamic neuroendocrine stress pathways in rats with no extrinsic behavioral stress applied.Scientific reports · 2025Article
- Experimental murine models of interstitial cystitis/bladder pain syndrome: A review.Histology and histopathology · 2025Review
- Intravesical nerve growth factor antisense therapy for bladder hypersensitivity induced by psychological stress.Gene therapy · 2024Article
- Article
- TRPV1 and mast cell involvement in repeated variate stress-induced urinary bladder dysfunction in adult female mice.American journal of physiology. Renal physiology · 2024Article
- Mechanisms of oxidative stress in interstitial cystitis/bladder pain syndrome.Nature reviews. Urology · 2024Review
- Mental health problems, stressful life events and new-onset urinary incontinence in primary school-age children: a prospective cohort study.European child & adolescent psychiatry · 2024Article
- Stressed snails releaseOne health (Amsterdam, Netherlands) · 2023Article
- The Innovative Approach in Functional Bladder Disorders: The Communication Between Bladder and Brain-Gut Axis.International neurourology journal · 2023Article
- Review
- Stress-induced bladder hypersensitivity: Effect of corticotropin releasing factor receptors assessed by spinal neurophysiology and neurochemistry.Neuropharmacology · 2023Article
- Repeated variate stress increased voiding frequency and altered TrpV1 and TrpV4 transcript expression in lower urinary tract (LUT) pathways in female mice.Frontiers in urology · 2023Article
- Stress-Induced Changes in Trophic Factor Expression in the Rodent Urinary Bladder: Possible Links With Angiogenesis.International neurourology journal · 2022Article
- Broaden Horizons: The Advancement of Interstitial Cystitis/Bladder Pain Syndrome.International journal of molecular sciences · 2022Review
- Neonatal cystitis alters mechanisms of stress-induced visceral hypersensitivity in rats.Neuroscience letters · 2022Article
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
objectivePsychological stress plays a role in the exacerbation of functional lower urinary tract disorders, such as painful bladder syndrome and overactive bladder. To better understand the mechanism underlying this relationship, we characterized changes in micturition, anxiety-related behavior, and bladder pathology in rats exposed to repeated water avoidance (WA) stress.
methodsTwenty-four Wistar rats were subjected to WA stress or sham. Immediately after acute (day 1) and chronic (day 10) stress or sham, rats were placed in a metabolic cage for a 2-hour voiding behavior assessment. Voiding parameters were compared with baseline values obtained before stress. Four animals from each group were sacrificed on day 10 and bladders harvested for histologic and gene expression studies. The remaining 8 animals per group underwent repeated voiding assessment every 3 days for 1 month followed by 10 days of repeat WA stress or sham. Bladder histology and gene expression were studied.
resultsRats exposed to WA stress developed a significant increase in micturition frequency and decrease in latency to void, voiding interval, and volume of first void compared with sham and baseline. Alterations in micturition persisted for approximately 1 month. Stressed rats showed increased fecal pellet excretion and anxiety-like behavior. In addition, bladder specimens from stressed animals revealed increased angiogenesis, and increased total and activated mast cells.
conclusionIn rats, repeated psychological stress results in lasting alterations in micturition frequency, interval, and volume. This rodent model may represent a valid tool for studying syndromes characterized by increased urinary frequency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.