ArticleChemistry & biology2011
Targeting MgrA-mediated virulence regulation in Staphylococcus aureus.
Article in Chemistry & biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 62 citations in OpenAlex.
- Efflux pump modulation by Montelukast and its roles in restoring antibiotic susceptibility in multidrug-resistant Staphylococcus aureus.EBioMedicine · 2025Article
- Epigenetic background of lineage-specific gene expression landscapes of four Staphylococcus aureus hospital isolates.PloS one · 2025Article
- Exploring the potential of isorhapontigenin: attenuatingmSphere · 2024Article
- Thwarting resistance: MgrA inhibition with methylophiopogonanone a unveils a new battlefront against S. aureus.NPJ biofilms and microbiomes · 2024Article
- Diflunisal and Analogue Pharmacophores Mediating Suppression of Virulence Phenotypes inAntibiotics (Basel, Switzerland) · 2023Article
- A structure activity relationship study of 3,4'-dimethoxyflavone for ArlRS inhibition inOrganic & biomolecular chemistry · 2023Article
- Genomic alterations involved in fluoroquinolone resistance development in Staphylococcus aureus.PloS one · 2023Article
- Nepetin reduces virulence factors expression by targeting ClpP against MRSA-induced pneumonia infection.Virulence · 2022Article
- Covalent sortase A inhibitor ML346 preventsRSC medicinal chemistry · 2022Article
- Prevalence and antimicrobial resistance profiling of3 Biotech · 2022Article
- Antibiotic resistance alters through iron-regulating Sigma factors during the interaction of Staphylococcus aureus and Pseudomonas aeruginosa.Scientific reports · 2021Article
- Salicylic acid stabilizes Staphylococcus aureus biofilm by impairing the agr quorum-sensing system.Scientific reports · 2021Article
- The Role ofFrontiers in microbiology · 2021Article
- Stp1 Loss of Function Promotes β-Lactam Resistance in Staphylococcus aureus That Is Independent of Classical Genes.Antimicrobial agents and chemotherapy · 2020Article
- The Staphylococcus aureus ArlRS two-component system regulates virulence factor expression through MgrA.Molecular microbiology · 2020Article
- The inhibitory mechanism of aurintricarboxylic acid targeting serine/threonine phosphatase Stp1 in Staphylococcus aureus: insights from molecular dynamics simulations.Acta pharmacologica Sinica · 2019Article
- Staphylococcus aureus adhesion in endovascular infections is controlled by the ArlRS-MgrA signaling cascade.PLoS pathogens · 2019Article
- The role of ArlRS in regulating oxacillin susceptibility in methicillin-resistant Staphylococcus aureus indicates it is a potential target for antimicrobial resistance breakers.Emerging microbes & infections · 2019Article
- Structure-activity relationships of pyrazole-4-carbodithioates as antibacterials against methicillin-resistant Staphylococcus aureus.Bioorganic & medicinal chemistry letters · 2018Article
- Suppression ofProceedings of the National Academy of Sciences of the United States of America · 2018Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Increasing antibiotic resistance in human pathogens necessitates the development of new approaches against infections. Targeting virulence regulation at the transcriptional level represents a promising strategy yet to be explored. A global transcriptional regulator, MgrA in Staphylococcus aureus, was identified previously as a key virulence determinant. We have performed a fluorescence anisotropy (FA)-based high-throughput screen that identified 5, 5-methylenedisalicylic acid (MDSA), which blocks the DNA binding of MgrA. MDSA represses the expression of α-toxin that is up-regulated by MgrA and activates the transcription of protein A, a gene down-regulated by MgrA. MDSA alters bacterial antibiotic susceptibilities via an MgrA-dependent pathway. A mouse model of infection indicated that MDSA could attenuate S. aureus virulence. This work is a rare demonstration of utilizing small molecules to block protein-DNA interaction, thus tuning important biological regulation at the transcriptional level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.