ArticleNeuron2011
Cadherin-9 regulates synapse-specific differentiation in the developing hippocampus.
Article in Neuron, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.
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Who cites it
126 citing papers in PubMed.
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- Elevated synaptic PKA activity and abnormal striatal dopamine signaling in Akap11 mutant mice, a genetic model of schizophrenia and bipolar disorder.Nature communications · 2025Article
- Elevated synaptic PKA activity and abnormal striatal dopamine signaling inbioRxiv : the preprint server for biology · 2025Article
- Identifying Tipping Points during Healthy Brain Aging through Single-Nucleus Transcriptomic Analysis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A dynamic gene regulatory code drives synaptic development of hippocampal granule cells.Science advances · 2025Article
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- 11.7T Diffusion Magnetic Resonance Imaging and Tractography to Probe Human Brain Organoid Microstructure.Biological psychiatry global open science · 2024Article
- Classical cadherins evolutionary constraints in primates is associated with their expression in the central nervous system.PloS one · 2024Article
- Dual-specificity protein phosphatase 6 (DUSP6) overexpression reduces amyloid load and improves memory deficits in male 5xFAD mice.Frontiers in aging neuroscience · 2024Article
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- Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window.bioRxiv : the preprint server for biology · 2023Article
- Catenin signaling controls phrenic motor neuron development and function during a narrow temporal window.Frontiers in neural circuits · 2023Article
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- Cortical wiring by synapse type-specific control of local protein synthesis.Science (New York, N.Y.) · 2022Article
- Ascertaining cells' synaptic connections and RNA expression simultaneously with barcoded rabies virus libraries.Nature communications · 2022Article
- Neuropilin-2 Signaling Modulates Mossy Fiber Sprouting by Regulating Axon Collateral Formation Through CRMP2 in a Rat Model of Epilepsy.Molecular neurobiology · 2022Article
66 more citing papers are in PubMed but not listed here.
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Authors and funding
11 authors.
Funding
Abstract
Our understanding of mechanisms that regulate the differentiation of specific classes of synapses is limited. Here, we investigate the formation of synapses between hippocampal dentate gyrus (DG) neurons and their target CA3 neurons and find that DG neurons preferentially form synapses with CA3 rather than DG or CA1 neurons in culture, suggesting that specific interactions between DG and CA3 neurons drive synapse formation. Cadherin-9 is expressed selectively in DG and CA3 neurons, and downregulation of cadherin-9 in CA3 neurons leads to a selective decrease in the number and size of DG synapses onto CA3 neurons. In addition, loss of cadherin-9 from DG or CA3 neurons in vivo leads to striking defects in the formation and differentiation of the DG-CA3 mossy fiber synapse. These observations indicate that cadherin-9 bidirectionally regulates DG-CA3 synapse development and highlight the critical role of differentially expressed molecular cues in establishing specific connections in the mammalian brain.
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