ArticleBMC clinical pathology2011
Functional characterization of the complement receptor type 1 and its circulating ligands in patients with schizophrenia.
Article in BMC clinical pathology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 29 citations in OpenAlex.
- Complement receptor 1 gene polymorphisms are associated with cardiovascular risk.Atherosclerosis · 2017Trial
- Altered expression of complement regulatory proteins CD35 and CD59 in acute lymphoblastic and acute myeloblastic leukemia suggests a context-based pattern.Discover oncology · 2026Article
- The complement system in neurodegenerative and inflammatory diseases of the central nervous system.Frontiers in neurology · 2024Review
- Roles of complement system in psychiatric disorders.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
- Evaluation of Serum Complement Levels and Factors Affecting Treatment Resistance in Patients with Schizophrenia.Psychiatry and clinical psychopharmacology · 2023Article
- Dysregulation of complement system in neuropsychiatric disorders: A mini review.Biomarkers in neuropsychiatry · 2022Article
- Neuronal oscillations: early biomarkers of psychiatric disease?Frontiers in behavioral neuroscience · 2022Review
- Aberrant Complement System Activation in Neurological Disorders.International journal of molecular sciences · 2021Review
- Complement System in Brain Architecture and Neurodevelopmental Disorders.Frontiers in neuroscience · 2020Review
- The complement system in schizophrenia: where are we now and what's next?Molecular psychiatry · 2020Review
- Complement Receptor 1 (CR1, CD35) Polymorphisms and Soluble CR1: A Proposed Anti-inflammatory Role to Quench the Fire of "Fogo Selvagem" Pemphigus Foliaceus.Frontiers in immunology · 2019Article
- Autoimmune phenotypes in schizophrenia reveal novel treatment targets.Pharmacology & therapeutics · 2018Review
- Transcriptome sequencing study implicates immune-related genes differentially expressed in schizophrenia: new data and a meta-analysis.Translational psychiatry · 2017Article
- Increased Levels of C1q in the Prefrontal Cortex of Adult Offspring after Maternal Immune Activation: Prevention by 7,8-Dihydroxyflavone.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2017Article
- Towards an Immunophenotype of Schizophrenia: Progress, Potential Mechanisms, and Future Directions.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Review
- Autoimmune diseases, gastrointestinal disorders and the microbiome in schizophrenia: more than a gut feeling.Schizophrenia research · 2016Review
- The Gut Microbiota and the Emergence of Autoimmunity: Relevance to Major Psychiatric Disorders.Current pharmaceutical design · 2016Review
- Role of Immune and Autoimmune Dysfunction in Schizophrenia.Handbook of behavioral neuroscience · 2016Article
- Maternal complement C1q and increased odds for psychosis in adult offspring.Schizophrenia research · 2014Article
- Innate immunity and neuroinflammation.Mediators of inflammation · 2013Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWhereas the complement system alterations contribute to schizophrenia, complement receptors and regulators are little studied. We investigated complement receptor type 1 (CR1) expression on blood cells, the levels of circulating immune complexes (CIC) containing ligands of CR1, C1q complement protein and fragments of C3 complement protein (C1q-CIC, C3d-CIC), and CR1 C5507G functional polymorphism in schizophrenia patients and controls.
resultsWe found an increased C1q-CIC level and CR1 expression on blood cells, elevated number of CR1 positive erythrocytes and reduced number of CR1 positive lymphocytes and monocytes in patients compared to controls. No difference in the levels of C3d-CIC between groups was observed. Higher CR1 expression on erythrocytes in CC genotype versus CG+GG for both groups was detected, whereas no difference was observed for other cell populations. Our results indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level.
conclusionsOur study for the first time indicated that schizophrenia is associated with the increased CR1 expression and C1q-CIC level. Further studies in other ethnic groups are needed to replicate these findings.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.