ArticleBMC systems biology2011
MicroRNAs coordinately regulate protein complexes.
Article in BMC systems biology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 59 citations in OpenAlex.
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- The EMT activator ZEB1 accelerates endosomal trafficking to establish a polarity axis in lung adenocarcinoma cells.Nature communications · 2021Article
- MicroRNA Signatures of the Developing Primate Fovea.Frontiers in cell and developmental biology · 2021Article
- Analyzing the regulation of miRNAs on protein-protein interaction network in Hodgkin lymphoma.BMC bioinformatics · 2019Article
- Biclustering analysis of transcriptome big data identifies condition-specific microRNA targets.Nucleic acids research · 2019Article
- Molecular Network-Based Identification of Competing Endogenous RNAs in Thyroid Carcinoma.Genes · 2018Article
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- Evidence linking microRNA suppression of essential prosurvival genes with hippocampal cell death after traumatic brain injury.Scientific reports · 2017Article
- ceRNA crosstalk stabilizes protein expression and affects the correlation pattern of interacting proteins.Scientific reports · 2017Article
- Recent progress on the effects of microRNAs and natural products on tumor epithelial-mesenchymal transition.OncoTargets and therapy · 2017Review
- A network-biology perspective of microRNA function and dysfunction in cancer.Nature reviews. Genetics · 2016Review
- Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs.Nature communications · 2016Article
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- MicroRNA-Target Network Inference and Local Network Enrichment Analysis Identify Two microRNA Clusters with Distinct Functions in Head and Neck Squamous Cell Carcinoma.International journal of molecular sciences · 2015Article
- The miR-200 family and its targets regulate type II cell differentiation in human fetal lung.The Journal of biological chemistry · 2015Article
- Concordant dysregulation of miR-5p and miR-3p arms of the same precursor microRNA may be a mechanism in inducing cell proliferation and tumorigenesis: a lung cancer study.RNA (New York, N.Y.) · 2015Article
- miREC: a database of miRNAs involved in the development of endometrial cancer.BMC research notes · 2015Article
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn animals, microRNAs (miRNAs) regulate the protein synthesis of their target messenger RNAs (mRNAs) by either translational repression or deadenylation. miRNAs are frequently found to be co-expressed in different tissues and cell types, while some form polycistronic clusters on genomes. Interactions between targets of co-expressed miRNAs (including miRNA clusters) have not yet been systematically investigated.
resultsHere we integrated information from predicted and experimentally verified miRNA targets to characterize protein complex networks regulated by human miRNAs. We found striking evidence that individual miRNAs or co-expressed miRNAs frequently target several components of protein complexes. We experimentally verified that the miR-141-200c cluster targets different components of the CtBP/ZEB complex, suggesting a potential orchestrated regulation in epithelial to mesenchymal transition.
conclusionsOur findings indicate a coordinate posttranscriptional regulation of protein complexes by miRNAs. These provide a sound basis for designing experiments to study miRNA function at a systems level.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.