ArticleRejuvenation research2011
Combined exercise and insulin-like growth factor-1 supplementation induces neurogenesis in old rats, but do not attenuate age-associated DNA damage.
Article in Rejuvenation research, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed, 50 citations in OpenAlex.
- The role of exercise in modulating NAD+ metabolic enzymes: mechanisms and health benefits.Frontiers in sports and active living · 2026Review
- Altered accumulation of hepatic mitochondrial antioxidant proteins with age and environmental heat stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Article
- Exogenous lactate augments exercise-induced improvement in memory but not in hippocampal neurogenesis.Scientific reports · 2023Article
- Voluntary exercise does not increase gastrointestinal motility but increases spatial memory, intestinal eNOS, Akt levels, andFrontiers in physiology · 2023Article
- Review
- The Role of SIRT3 in Exercise and Aging.Cells · 2022Review
- Acute aerobic exercise-conditioned serum reduces colon cancer cell proliferation in vitro through interleukin-6-induced regulation of DNA damage.International journal of cancer · 2022Article
- Chronic exercise remodels the lysine acetylome in the mouse hippocampus.Frontiers in molecular neuroscience · 2022Article
- The effects of voluntary complex and regular wheel running exercises on the levels of 8-oxoguanine DNA glycosylase, semaphorin 3B, H2O2, and apoptosis in the hippocampus of diabetic rats.Brain and behavior · 2021Article
- The systemic role of SIRT1 in exercise mediated adaptation.Redox biology · 2020Review
- Aerobic endurance capacity affects spatial memory and SIRT1 is a potent modulator of 8-oxoguanine repair.Neuroscience · 2013Article
- Low-intensity treadmill exercise and/or bright light promote neurogenesis in adult rat brain.Neural regeneration research · 2013Article
- Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling.Antioxidants & redox signaling · 2013Review
- Wnt Signaling in Neurogenesis during Aging and Physical Activity.Brain sciences · 2012Article
- Base excision repair in physiology and pathology of the central nervous system.International journal of molecular sciences · 2012Review
- New Neurons in Aging Brains: Molecular Control by Small Non-Coding RNAs.Frontiers in neuroscience · 2012Article
- Exercise as Gene Therapy: BDNF and DNA Damage Repair.Asia-Pacific journal of ophthalmology (Philadelphia, Pa.)Review
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 4 countries.
Funding
Abstract
We have investigated the effects of 2 weeks of insulin-like growth factor-1 (IGF-1) supplementation (5 μg/kg per day) and 6 weeks of exercise training (60% of the maximal oxygen consumption [VO₂ max]) on neurogenesis, DNA damage/repair, and sirtuin content in the hippocampus of young (3 months old) and old (26 months old) rats. Exercise improved the spatial memory of the old group, but IGF-1 supplementation eliminated this effect. An age-associated decrease in neurogenesis was attenuated by exercise and IGF-1 treatment. Aging increased the levels of 8-oxo-7,8-dihydroguanine (8-oxoG) and the protein Ku70, indicating the role of DNA damage in age-related neuropathology. Acetylation of 8-oxoguanine DNA glycosylase (OGG1) was detected in vivo, and this decreased with aging. However, in young animals, exercise and IGF-1 treatment increased acetylated (ac) OGG1 levels. Sirtuin 1 (SIRT1) and SIRT3, as DNA damage-associated lysine deacetylases, were measured, and SIRT1 decreased with aging, resulting in a large increase in acetylated lysine residues in the hippocampus. On the other hand, SIRT3 increased with aging. Exercise-induced neurogenesis might not be a causative factor of increased spatial memory, because IGF-1 plus exercise can induce neurogenesis in the hippocampus of older rats. Data revealed that the age-associated increase in 8-oxoG levels is due to decreased acetylation of OGG1. Age-associated decreases in SIRT1 and the associated increase in lysine acetylation, in the hippocampus, could have significant impact on function and thus, could suggest a therapeutic target.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.