Evidence map›Paper›PMID 21866967›Full record

ArticleJournal of the American Chemical Society2011

Emissive RNA alphabet.

Dongwon Shin, Renatus W Sinkeldam, Yitzhak Tor

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 76 papers.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Cytidine and dCMP Deaminases-Current Methods of Activity Analysis.International journal of molecular sciences · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Site-specific RNA modificationRSC chemical biology · 2024
    Article
  11. Isomorphic Fluorescent Nucleosides.Accounts of chemical research · 2024
    Article
  12. Article
  13. Inherently Emissive Puromycin Analogues for Live Cell Labelling.Angewandte Chemie (International ed. in English) · 2023
    Article
  14. Article
  15. Article
  16. Miniaturized Chemical Tags for Optical Imaging.Angewandte Chemie (International ed. in English) · 2022
    Review
  17. Article
  18. Article
  19. Chemical Synthesis of the Fluorescent, Cyclic Dinucleotides cChembiochem : a European journal of chemical biology · 2022
    Article
  20. A New Variant of Emissive RNA Alphabets.Chemistry (Weinheim an der Bergstrasse, Germany) · 2022
    Article

16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Dongwon ShinDepartment of Chemistry and Biochemistry, University of California, San Diego, La Jolla, California 92093-0358, United States.
Renatus W Sinkeldam
Yitzhak Tor

Funding

Fluorescent Nucleosides and OligonucleotidesR01GM069773 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TOR, YITZHAK · 2004 to 2020
$5.0M
NIGMS NIH HHS GM 069773NIGMS NIH HHS R01 GM069773
6 · The paper itself

Abstract

A fluorescent ribonucleoside alphabet consisting of highly emissive purine ((th)A, (th)G) and pyrimidine ((th)U, (th)C) analogues, all derived from thieno[3,4-d]pyrimidine as the heterocyclic nucleus, is described. Structural and biophysical analyses demonstrated that the emissive analogues are faithful isomorphic nucleoside surrogates. Photophysical analysis established that the nucleosides offer highly desirable qualities, including visible emission, high quantum yield, and responsiveness to environmental perturbations, traits entirely lacking in their native counterparts.

Indexed as

Crystallography, X-RayFluorescenceModels, MolecularMolecular ConformationPyrimidinesRNAStereoisomerismpyrimidinePyrimidinesRNA

Identifiers

PMID21866967
PMCPMC3179766

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.