ReviewEuropean archives of psychiatry and clinical neuroscience2011
Schizophrenia as a disorder of disconnectivity.
Review in European archives of psychiatry and clinical neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 111 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
111 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2,833 individuals with schizophrenia compared with 3,929 healthy volunteers via the ENIGMA Consortium.Human brain mapping · 2022Pooled it
- Cannabis abuse and brain morphology in schizophrenia: a review of the available evidence.European archives of psychiatry and clinical neuroscience · 2013Pooled it
- Transcranial direct current stimulation and cognitive training in the treatment of cognitive deficit in schizophrenia: a randomized controlled trial.BMC psychiatry · 2026Trial
- Videogame training increases clinical well-being, attention and hippocampal-prefrontal functional connectivity in patients with schizophrenia.Translational psychiatry · 2024Trial
- Trial
- The effect of aerobic exercise on cortical architecture in patients with chronic schizophrenia: a randomized controlled MRI study.European archives of psychiatry and clinical neuroscience · 2013Trial
- Concomitant pathologies and their impact on schizophrenia: a narrative overview of current evidence.Journal of neural transmission (Vienna, Austria : 1996) · 2026Review
- Classifying schizophrenia patients and healthy individuals: Whole brain SPECT functional connectivity using support vector machine classification.Neuroimage. Reports · 2026Article
- Schizophrenia detection via lobe-wise and overall EEG features using VMD and bayesian-optimized machine learning models.Frontiers in neuroscience · 2026Article
- MesoSCOUT: A novel tool for revealing mesoscale organization in the white-matter connectome.bioRxiv : the preprint server for biology · 2025Article
- A frame network study of first-episode schizophrenia, ultra-high risk, and healthy populations.Schizophrenia (Heidelberg, Germany) · 2025Article
- Minimum spanning tree analysis of EEG resting-state functional networks in schizophrenia.Scientific reports · 2024Article
- Common risk alleles for schizophrenia within the major histocompatibility complex predict white matter microstructure.Translational psychiatry · 2024Article
- White matter tract alterations in schizophrenia identified by DTI-based probabilistic tractography: a multisite harmonisation study.Acta neuropsychiatrica · 2024Article
- Disturbed Oligodendroglial Maturation Causes Cognitive Dysfunction in Schizophrenia: A New Hypothesis.Schizophrenia bulletin · 2023Article
- Brain-derived neurotrophic factor (BDNF) in schizophrenia research: a quantitative review and future directions.AIMS neuroscience · 2023Review
- Alteration of a brain network with stable and strong functional connections in subjects with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2022Article
- Association between aerobic fitness and the functional connectome in patients with schizophrenia.European archives of psychiatry and clinical neuroscience · 2022Article
- Article
- Angle-tuned coils: attractive building blocks for TMS with improved depth-spread performance.Journal of neural engineering · 2022Article
51 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Schizophrenia is considered as a neurodevelopmental disorder with genetic and environmental factors playing a role. Animal models show that developmental hippocampal lesions are causing disconnectivity of the prefrontal cortex. Magnetic resonance imaging and postmortem investigations revealed deficits in the temporoprefrontal neuronal circuit. Decreased oligodendrocyte numbers and expression of oligodendrocyte genes and synaptic proteins may contribute to disturbances of micro- and macro-circuitry in the pathophysiology of the disease. Functional connectivity between cortical areas can be investigated with high temporal resolution using transcranial magnetic stimulation (TMS), electroencephalography (EEG), and magnetoencephalography (MEG). In this review, disconnectivity between different cortical areas in schizophrenia patients is described. The specificity and the neurobiological origin of these connectivity deficits and the relation to the symptom complex of schizophrenia and the glutamatergic and GABAergic system are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.