ArticleIntensive care medicine2011
Outcomes of mechanically ventilated hematology patients with invasive pulmonary aspergillosis.
Article in Intensive care medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 4 of them syntheses that pooled it.
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Who cites it
35 citing papers in PubMed, 4 syntheses or guidelines pooled it, 68 citations in OpenAlex.
- Changes in critically ill cancer patients' short-term outcome over the last decades: results of systematic review with meta-analysis on individual data.Intensive care medicine · 2019Pooled it
- Influence of neutropenia on mortality of critically ill cancer patients: results of a meta-analysis on individual data.Critical care (London, England) · 2018Pooled it
- A systematic review of prognostic factors at the end of life for people with a hematological malignancy.BMC cancer · 2017Pooled it
- Diagnosis and antimicrobial therapy of lung infiltrates in febrile neutropenic patients (allogeneic SCT excluded): updated guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO).Annals of oncology : official journal of the European Society for Medical Oncology · 2015Guideline
- In-Hospital Mortality Among Hematological Malignancy Patients Undergoing Bronchoscopy for Suspected Invasive Pulmonary Aspergillosis: Focusing on Coinfections and Nodules on Chest CT.Mycopathologia · 2025Article
- A multivariable prediction model for invasive pulmonary aspergillosis in immunocompromised patients with acute respiratory failure (IPA-GRRR-OH score).Intensive care medicine · 2025Article
- Fungal infections in immunocompromised critically ill patients.Journal of intensive medicine · 2024Review
- Anticipatory Antifungal Treatment in Critically Ill Patients with SARS-CoV-2 Pneumonia.Journal of fungi (Basel, Switzerland) · 2023Article
- Routine Surveillance of Healthcare-Associated Infections Misses a Significant Proportion of Invasive Aspergillosis in Patients with Severe COVID-19.Journal of fungi (Basel, Switzerland) · 2022Article
- Neutrophile-to-Lymphocyte Ratio as a Predictor of Mortality and Response to Treatment in Invasive Aspergillosis among Heart Transplant Recipients-Exploratory Study.Medicina (Kaunas, Lithuania) · 2021Article
- Prognostic Scores and Azole-ResistantJournal of fungi (Basel, Switzerland) · 2021Article
- Failure of Noninvasive Ventilation in Acute Respiratory Failure is Associated with Higher Mortality in Patients with Solid Tumors: A Retrospective Cohort Study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Prevalence and clinical course of upper airway respiratory virus infection in critically ill patients with hematologic malignancies.PloS one · 2021Observational
- Hematological malignancies in Polish population: what are the predictors of outcome in patients admitted to Intensive Care Unit?Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021Article
- Article
- Observational
- Invasive pulmonary aspergillosis in critically ill patients with hematological malignancies.Intensive care medicine · 2019Article
- Epidemiology of invasive pulmonary aspergillosis in patients with liver failure: Clinical presentation, risk factors, and outcomes.The Journal of international medical research · 2018Article
- Acute hypoxemic respiratory failure in immunocompromised patients: the Efraim multinational prospective cohort study.Intensive care medicine · 2017Observational
- A new time-dependent approach for assessment of the impact of invasive aspergillosis shows effect on short- but not on long-term survival of patients with AML or high-risk MDS.Bone marrow transplantation · 2017Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInvasive pulmonary aspergillosis (IPA) is a life-threatening infection documented in up to 15% of hematology patients who require intensive care for acute respiratory failure. We report outcomes in hematology patients given mechanical ventilation (MV) with IPA.
methodsRetrospective study of all hematology patients given MV with IPA between January 1998 and March 2011 at a single center. Predictors of 6-month survival or mortality were identified using multivariable analysis.
resultsWe studied 67 patients including 49 (73%) with neutropenia, 23 (34%) with long-term steroid therapy, and 14 (21%) with allogeneic bone marrow transplantation. Incidence of IPA in the ICU decreased between 1998 and 2011, and mortality in patients receiving mechanical ventilation did not change. IPA was confirmed in 6 patients by autopsy and was probable in 61 patients based on host factors, clinical and radiographic features, and either Aspergillus isolation (50 patients) or Aspergillus antigen detection alone (11 patients). Concomitant bacterial infections were documented in 24 (36%) patients. ICU and 6-month mortality rates were 67 and 82%, respectively. Mortality was stable throughout the study period. Concomitant bacterial infection was independently associated with higher mortality [HR, 2.1 (1.2-3.8)]. Mortality was lower in patients given voriconazole [OR, 0.5 (0.3-0.9)].
conclusionHospital mortality remains high in hematology patients requiring MV with IPA, particularly when concommittant infection occurred. The use of voriconazole improved survival.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.