ArticleHuman genetics2012
The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations.
Article in Human genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
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Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Quantitative assessment of common genetic variants on chromosome 5p15 and lung cancer risk.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Pooled it
- Association of MDM2 SNP309 variation with lung cancer risk: evidence from 7196 cases and 8456 controls.PloS one · 2012Pooled it
- Bioinformatics analysis of PSAT1 loss identifies downstream pathways regulated in EGFR mutant NSCLC and a selective gene signature for predicting the risk of relapse.Oncology letters · 2025Article
- Single nucleotide variants in lung cancer.Chinese medical journal pulmonary and critical care medicine · 2024Review
- Lung cancer in patients who have never smoked - an emerging disease.Nature reviews. Clinical oncology · 2024Review
- Genome-wide analysis study of gestational diabetes mellitus and related pathogenic factors in a Chinese Han population.BMC pregnancy and childbirth · 2023Article
- Etiology of lung cancer: Evidence from epidemiologic studies.Journal of the National Cancer Center · 2022Review
- Lung cancer risk in never-smokers: An overview of environmental and genetic factors.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2021Article
- The effect of susceptibility variants, identified in never-smoking female lung cancer cases, on male smokers.The Korean journal of internal medicine · 2020Article
- Potential Genes Associated with the Survival of Lung Adenocarcinoma Were Identified by Methylation.Computational and mathematical methods in medicine · 2020Article
- Gene polymorphism of DNA repair gene X-ray repair cross complementing group 1 and xeroderma pigmentosum group D and environment interaction in non-small-cell lung cancer for Chinese nonsmoking female patients.The Kaohsiung journal of medical sciences · 2019Article
- A Decade of GWAS Results in Lung Cancer.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2018Review
- Telomerase Reverse Transcriptase Polymorphism rs2736100: A Balancing Act between Cancer and Non-Cancer Disease, a Meta-Analysis.Frontiers in medicine · 2018Article
- Genome-wide association study confirms lung cancer susceptibility loci on chromosomes 5p15 and 15q25 in an African-American population.Lung cancer (Amsterdam, Netherlands) · 2016Article
- The study of the relation of DNA repair pathway genes SNPs and the sensitivity to radiotherapy and chemotherapy of NSCLC.Scientific reports · 2016Article
- Epidemiology of Lung Cancer in Korea: Recent Trends.Tuberculosis and respiratory diseases · 2016Review
- Gene mutation discovery research of non-smoking lung cancer patients due to indoor radon exposure.Annals of occupational and environmental medicine · 2016Review
- Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung.Carcinogenesis · 2014Article
- Single-nucleotide polymorphism (c.309T>G) in theBiomedical reports · 2014Article
- Association between TERT rs2736100 polymorphism and lung cancer susceptibility: evidence from 22 case-control studies.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
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Authors and funding
16 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The proportion of never smoker non-small cell lung cancer (NSCLC) in Asia is about 30-40%. Despite the striking demographics and high prevalence of never smoker NSCLC, the exact causes still remain undetermined. Although several genome wide association (GWA) studies were conducted to find susceptibility loci for lung cancer in never smokers, no regions were replicated except for 5p15.33, suggesting locus heterogeneity and different environmental toxic effects. To identify genetic loci associated with susceptibility of lung cancer in never smokers, we performed a GWA analysis using the Affymetrix 6.0 SNP array. For discovery GWA set, we recruited 446 never smoking Korean patients with NSCLC and 497 normal subjects. We tested association of SNPs with lung cancer susceptibility using the Cochran-Armitage trend test. For validation, 39 SNPs were selected from the top 50 SNPs and five additional SNPs were selected in the DAB1 gene region which showed significant associations in the GWA analysis. The validation SNPs were genotyped in an independent sample including 434 patients and 1,000 controls. Among the 44 validation SNPs, two SNPs (rs11080466 and rs11663246) near the APCDD1, NAPG and FAM38B genes in the 18p11.22 region were replicated. P value of rs11080466 was 1.08 × 10(-6) in the combined sets (2.68 × 10(-5) in the discovery set and 2.60 × 10(-3) in the validation set) and odds ratio was 0.68 (0.58-0.79). We observed similar association for rs11663246. Our result suggests the 18p11.22 region as a novel lung cancer susceptibility locus in never smokers.
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