Evidence map›Paper›PMID 21866275›Full record

ArticleSpermatogenesis2011

Desmosomes in the testis: Moving into an unchartered territory.

Dolores D Mruk, C Yan Cheng

Open access · bronzeAbstract read
In one paragraph

Article in Spermatogenesis, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
6.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Kinesins in Mammalian Spermatogenesis and Germ Cell Transport.Frontiers in cell and developmental biology · 2022
    Review
  4. Androgen Actions in the Testis and the Regulation of Spermatogenesis.Advances in experimental medicine and biology · 2021
    Review
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Actin binding proteins, spermatid transport and spermiation.Seminars in cell & developmental biology · 2014
    Review
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Dolores D MrukThe Population Council; Center for Biomedical Research; New York, NY USA.
C Yan Cheng
New York Proton Center · USPopulation Council · US

Funding

SPECIALIZED CONTRACEPTIVE DEVELOPMENT RESEARCH CENTERU54HD029990 · NICHD · POPULATION COUNCIL · PI CHENG, C. YAN · 1992 to 2016
$27.7M
The biology of blood-testis barrier dynamicsR01HD056034 · NICHD · POPULATION COUNCIL · PI CHENG, C. YAN · 2009 to 2018
$3.4M
Biology of desmosome-gap junctions in the testisR03HD061401 · NICHD · POPULATION COUNCIL · PI MRUK, DOLORES D · 2009 to 2010
$160k
NICHD NIH HHS R01 HD056034NICHD NIH HHS R03 HD061401NICHD NIH HHS U54 HD029990
6 · The paper itself

Abstract

Desmosomes are cell-cell junctions that link to cytoplasmic intermediate filaments, and they are known to mediate robust and stable adhesion in organs such as the skin and heart. Desmosomes are also present between apposing Sertoli cells at the blood-testis barrier, and between Sertoli cells and all germ cells up to, but not including, step 8 spermatids in the seminiferous epithelium. Unfortunately, they remain to be one of the least studied cell junction types in the seminiferous epithelium of the mammalian testis. In this article, we briefly discuss how kinases and the actin cytoskeleton relate to the study of desmosomes in the testis. It is hoped that this information is used to initiate more studies on the biology of the desmosome in the future.

Identifiers

PMID21866275
PMCPMC3158645
OpenAlexW2320180478

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.