ArticleOpen access animal physiology2010
Auditory sensitivity and the outer hair cell system in the CBA mouse model of age-related hearing loss.
Article in Open access animal physiology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Resistance to age-related hearing loss in the echolocating big brown bat (Proceedings. Biological sciences · 2024Article
- Connexins 30 and 43 expression changes in relation to age-related hearing loss.Hearing research · 2024Article
- A novel dynamic network imaging analysis method reveals aging-related fragmentation of cortical networks in mouse.Network neuroscience (Cambridge, Mass.) · 2021Article
- Auditory Threshold Variability in the SAMP8 Mouse Model of Age-Related Hearing Loss: Functional Loss and Phenotypic Change Precede Outer Hair Cell Loss.Frontiers in aging neuroscience · 2021Article
- Zone-specific damage of the olfactory epithelium under protein restriction.Scientific reports · 2020Article
- The local translation ofAging · 2019Article
- Rapamycin but not acarbose decreases age-related loss of outer hair cells in the mouse Cochlea.Hearing research · 2018Article
- Effects of Long-Term Exercise on Age-Related Hearing Loss in Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The impact of aging, hearing loss, and body weight on mouse hippocampal redox state, measured in brain slices using fluorescence imaging.Neurobiology of aging · 2016Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Age-related hearing loss is a highly prevalent sensory disorder, from both the clinical and animal model perspectives. Understanding of the neurophysiologic, structural, and molecular biologic bases of age-related hearing loss will facilitate development of biomedical therapeutic interventions to prevent, slow, or reverse its progression. Thus, increased understanding of relationships between aging of the cochlear (auditory portion of the inner ear) hair cell system and decline in overall hearing ability is necessary. The goal of the present investigation was to test the hypothesis that there would be correlations between physiologic measures of outer hair cell function (otoacoustic emission levels) and hearing sensitivity (auditory brainstem response thresholds), starting in middle age. For the CBA mouse, a useful animal model of age-related hearing loss, it was found that correlations between these two hearing measures occurred only for high sound frequencies in middle age. However, in old age, a correlation was observed across the entire mouse range of hearing. These findings have implications for improved early detection of progression of age-related hearing loss in middle-aged mammals, including mice and humans, and distinguishing peripheral etiologies from central auditory system decline.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.