ArticleJournal of neuropathology and experimental neurology2011
Decreased GABAA receptor binding in the medullary serotonergic system in the sudden infant death syndrome.
Article in Journal of neuropathology and experimental neurology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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Who cites it
25 citing papers in PubMed, 44 citations in OpenAlex.
- Developmental mechanisms underlying pediatric epilepsy.Frontiers in neurology · 2025Review
- The vicious spiral in Sudden Infant Death Syndrome.Frontiers in pediatrics · 2025Review
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part II. Age-associated alterations in serotonin receptor binding profiles within medullary nuclei supporting cardiorespiratory homeostasis.Journal of neuropathology and experimental neurology · 2024Article
- Altered 5-HT2A/C receptor binding in the medulla oblongata in the sudden infant death syndrome (SIDS): Part I. Tissue-based evidence for serotonin receptor signaling abnormalities in cardiorespiratory- and arousal-related circuits.Journal of neuropathology and experimental neurology · 2023Article
- Orexin contributes to eupnea within a critical period of postnatal development.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- The Unfolded Protein Response in the Human Infant Brain and Dysregulation Seen in Sudden Infant Death Syndrome (SIDS).Molecular neurobiology · 2021Article
- Sudden Infant Death Syndrome: Beyond Risk Factors.Life (Basel, Switzerland) · 2021Review
- Maternally derived hormones, neurosteroids and the development of behaviour.Proceedings. Biological sciences · 2021Article
- Nicotinic Receptors in the Brainstem Ascending Arousal System in SIDS With Analysis of Pre-natal Exposures to Maternal Smoking and Alcohol in High-Risk Populations of the Safe Passage Study.Frontiers in neurology · 2021Article
- Prenatal intermittent hypoxia sensitizes the laryngeal chemoreflex, blocks serotoninergic shortening of the reflex, and reduces 5-HTExperimental neurology · 2020Article
- The Serotonin Brainstem Hypothesis for the Sudden Infant Death Syndrome.Journal of neuropathology and experimental neurology · 2019Review
- Neurochemical Alterations in Sudden Unexplained Perinatal Deaths-A Review.Frontiers in pediatrics · 2018Review
- Metabolomic profiling of brain from infants who died from Sudden Infant Death Syndrome reveals novel predictive biomarkers.Journal of perinatology : official journal of the California Perinatal Association · 2017Article
- Article
- Microbiome-Gut-Brain Axis: A Pathway for Improving Brainstem Serotonin Homeostasis and Successful Autoresuscitation in SIDS-A Novel Hypothesis.Frontiers in pediatrics · 2016Article
- Impaired arousal in rat pups with prenatal alcohol exposure is modulated by GABAergic mechanisms.Physiological reports · 2015Article
- Assigning cause for sudden unexpected infant death.Forensic science, medicine, and pathology · 2015Article
- A group of non-serotonergic cells is CO2-stimulated in the medullary raphé.Neuroscience · 2014Article
- Potential asphyxia and brainstem abnormalities in sudden and unexpected death in infants.Pediatrics · 2013Article
- Serotonin gene variants are unlikely to play a significant role in the pathogenesis of the sudden infant death syndrome.Respiratory physiology & neurobiology · 2013Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
γ-Aminobutyric acid (GABA) neurons in the medulla oblongata help regulate homeostasis, in part through interactions with the medullary serotonergic (5-HT) system. Previously, we reported abnormalities in multiple 5-HT markers in the medullary 5-HT system of infants dying from sudden infant death syndrome (SIDS), suggesting that 5-HT dysfunction is involved in its pathogenesis. Here, we tested the hypothesis that markers of GABAA receptors are decreased in the medullary 5-HT system in SIDS cases compared with controls. Using tissue receptor autoradiography with the radioligand H-GABA, we found 25% to 52% reductions in GABAA receptor binding density in 7 of 10 key nuclei sampled of the medullary 5-HT system in the SIDS cases (postconceptional age [PCA] = 51.7 ± 8.3, n = 28) versus age-adjusted controls (PCA = 55.3 ± 13.5, n = 8) (p ≤ 0.04). By Western blotting, there was 46.2% reduction in GABAAα3 subunit levels in the gigantocellularis (component of the medullary 5-HT system) of SIDS cases (PCA = 53.9 ± 8.4, n = 24) versus controls (PCA = 55.3 ± 8.3, n = 8) (56.8% standard in SIDS cases vs 99.35% in controls; p = 0.026). These data suggest that medullary GABAA receptors are abnormal in SIDS infants and that SIDS is a complex disorder of a homeostatic network in the medulla that involves deficits of the GABAergic and 5-HT systems.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.