ArticleThe Journal of clinical investigation2011
Uroguanylin: how the gut got another satiety hormone.
Article in The Journal of clinical investigation, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- The Important Role of Aquaglyceroporin 7 in Health and Disease.Biomolecules · 2024Review
- BEST4American journal of physiology. Cell physiology · 2024Review
- Association of Uroguanylin, Body Mass Index, and Waist Circumference: Sex Differences and Obesity Implications among a Sample of Iraqi Adults in Baghdad City.Journal of pharmacy & bioallied sciences · 2024Article
- Reduced Plasma Guanylin Levels Following EnterotoxigenicMicroorganisms · 2023Article
- Inflammatory Bowel Disease Through the Lens of Single-cell RNA-seq Technologies.Inflammatory bowel diseases · 2020Review
- Two distinct GUCY2C circuits with PMV (hypothalamic) and SN/VTA (midbrain) origin.Brain structure & function · 2019Article
- Article
- Circulating Pro-Uroguanylin Levels In Children And Their Relation To Obesity, Sex And Puberty.Scientific reports · 2018Article
- Pilot Study Measuring the Novel Satiety Hormone, Pro-Uroguanylin, in Adolescents With and Without Obesity.Journal of pediatric gastroenterology and nutrition · 2018Article
- Guanylyl cyclase C signaling axis and colon cancer prevention.World journal of gastroenterology · 2016Review
- Guanylin and uroguanylin stimulate lipolysis in human visceral adipocytes.International journal of obesity (2005) · 2016Article
- Uroguanylin levels in intestine and plasma are regulated by nutritional status in a leptin-dependent manner.European journal of nutrition · 2016Article
- Natriuretic hormones in brain function.Frontiers in endocrinology · 2014Review
- The receptor guanylyl cyclase type D (GC-D) ligand uroguanylin promotes the acquisition of food preferences in mice.Chemical senses · 2013Article
- Pendrin, a novel transcriptional target of the uroguanylin system.Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology · 2013Review
- Immunohistochemical Staining for Uroguanylin, a Satiety Hormone, is Decreased in Intestinal Tissue Specimens From Female Adolescents With Obesity.Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology SocietyArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Prouroguanylin is a gastrointestinal paracrine signal and prohormone that is secreted after nutrient ingestion. In this issue of the JCI, Valentino et al. show that prouroguanylin is converted to uroguanylin in the CNS, which can activate guanylyl cyclase 2C (GUCY2C) receptors in the brain to reduce food intake in mice. This 16-amino acid residue peptide is a novel component of the gut-brain axis that represents a new and unique opportunity to manipulate gut-brain signaling for therapeutic intervention in obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.