ArticlePlant physiology2011
Biosynthesis of the major tetrahydroxystilbenes in spruce, astringin and isorhapontin, proceeds via resveratrol and is enhanced by fungal infection.
Article in Plant physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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40 citing papers in PubMed, 130 citations in OpenAlex.
- A Scots pine 4-coumarate:CoA ligase with high cinnamic acid affinity is the primary candidate for pinosylvin biosynthesis.The Plant journal : for cell and molecular biology · 2026Article
- Fungi associated with Norway spruce and its bark beetles detoxify spruce defense compounds by conjugation to α-ribose.The ISME journal · 2026Article
- Detoxification of conifer antimicrobial defenses promotes entomopathogenic fungus infection of bark beetles.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Research progress on the biosynthesis and regulatory mechanisms of resveratrol in plants.Frontiers in plant science · 2026Review
- The mutualistic fungi of the bark beetleISME communications · 2026Article
- Biosynthesis of Piceatannol from Resveratrol in Grapevine Can Be Mediated by Cresolase-DependentPlants (Basel, Switzerland) · 2024Article
- Elevated nutrient supply can exert worse effects on Norway spruce than drought, viewed through chemical defence against needle rust.Tree physiology · 2023Article
- Astringin protects LPS-induced toxicity by suppressing oxidative stress and inflammation via suppression of PI3K/AKT/NF-κB pathway for pediatric acute lung injury.Naunyn-Schmiedeberg's archives of pharmacology · 2023Article
- Transcriptomic changes during the establishment of long-term methyl jasmonate-induced resistance in Norway spruce.Plant, cell & environment · 2022Article
- Chemical Traits that Predict Susceptibility of Pinus radiata to Marsupial Bark Stripping.Journal of chemical ecology · 2022Article
- Bark Beetle Attack History Does Not Influence the Induction of Terpene and Phenolic Defenses in Mature Norway Spruce (Frontiers in plant science · 2022Article
- The Bark ofPlants (Basel, Switzerland) · 2021Article
- Stability and Photoisomerization of Stilbenes Isolated from the Bark of Norway Spruce Roots.Molecules (Basel, Switzerland) · 2021Article
- Impact of Environmental Factors on Stilbene Biosynthesis.Plants (Basel, Switzerland) · 2021Review
- Combining QTL Mapping and Transcriptomics to Decipher the Genetic Architecture of Phenolic Compounds Metabolism in the Conifer White Spruce.Frontiers in plant science · 2021Article
- Interactions among Norway spruce, the bark beetleJournal of pest science · 2021Review
- Lignin from Tree Barks: Chemical Structure and Valorization.ChemSusChem · 2020Article
- Localization of (+)-Catechin inMolecules (Basel, Switzerland) · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stilbenes are dibenzyl polyphenolic compounds produced in several unrelated plant families that appear to protect against various biotic and abiotic stresses. Stilbene biosynthesis has been well described in economically important plants, such as grape (Vitis vinifera), peanut (Arachis hypogaea), and pine (Pinus species). However, very little is known about the biosynthesis and ecological role of stilbenes in spruce (Picea), an important gymnosperm tree genus in temperate and boreal forests. To investigate the biosynthesis of stilbenes in spruce, we identified two similar stilbene synthase (STS) genes in Norway spruce (Picea abies), PaSTS1 and PaSTS2, which had orthologs with high sequence identity in sitka (Picea sitchensis) and white (Picea glauca) spruce. Despite the conservation of STS sequences in these three spruce species, they differed substantially from angiosperm STSs. Several types of in vitro and in vivo assays revealed that the P. abies STSs catalyze the condensation of p-coumaroyl-coenzyme A and three molecules of malonyl-coenzyme A to yield the trihydroxystilbene resveratrol but do not directly form the dominant spruce stilbenes, which are tetrahydroxylated. However, in transgenic Norway spruce overexpressing PaSTS1, significantly higher amounts of the tetrahydroxystilbene glycosides, astringin and isorhapontin, were produced. This result suggests that the first step of stilbene biosynthesis in spruce is the formation of resveratrol, which is further modified by hydroxylation, O-methylation, and O-glucosylation to yield astringin and isorhapontin. Inoculating spruce with fungal mycelium increased STS transcript abundance and tetrahydroxystilbene glycoside production. Extracts from STS-overexpressing lines significantly inhibited fungal growth in vitro compared with extracts from control lines, suggesting that spruce stilbenes have a role in antifungal defense.
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