ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Endogenous brain-derived neurotrophic factor in the nucleus tractus solitarius tonically regulates synaptic and autonomic function.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
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Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Autonomic dysfunction and sudden death in patients with Rett syndrome: a systematic reviewJournal of psychiatry & neuroscience : JPN · 2020Pooled it
- Trial
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- Combined Probiotics and Phenolics in Western Diet-fed Rats Enhance Parasympathetic Tone in the Gut-Brain Axis by Attenuating Inflammasome Signaling, and Reshaping Gut Microbiome.Probiotics and antimicrobial proteins · 2026Article
- Vagus Nerve Stimulation Mitigates Sepsis-Induced Lung Injury via Pulmonary proBDNF Suppression.Journal of inflammation research · 2026Article
- The role of the prefrontal cortex in cocaine-induced noradrenaline release in the nucleus accumbens: a computational study.Biological cybernetics · 2025Article
- Brain-Derived Neurotrophic Factor, Nociception, and Pain.Biomolecules · 2024Review
- K252a Prevents Microglial Activation Induced by Anoxic Stimulation of Carotid Bodies in Rats.Toxics · 2023Article
- Plasma and Urinary Levels of Nerve Growth Factor Are Elevated in Primary Hypertension.International journal of hypertension · 2022Article
- Do Neurotrophins Connect Neurological Disorders and Heart Diseases?Biomolecules · 2021Review
- Sedentary Conditions Promote Subregionally Specific Changes in Brain-Derived Neurotrophic Factor in the Rostral Ventrolateral Medulla.Frontiers in physiology · 2021Article
- Social defeat: Vagal reduction and vulnerability to ventricular arrhythmias.Neurobiology of stress · 2020Article
- BDNF Activates Postsynaptic TrkB Receptors to Induce Endocannabinoid Release and Inhibit Presynaptic Calcium Influx at a Calyx-Type Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Nerve growth factor activates autophagy in Schwann cells to enhance myelin debris clearance and to expedite nerve regeneration.Theranostics · 2020Article
- BDNF downregulates β-adrenergic receptor-mediated hypotensive mechanisms in the paraventricular nucleus of the hypothalamus.American journal of physiology. Heart and circulatory physiology · 2019Article
- Do Disruptions in the Circadian Timing System Contribute to Autonomic Dysfunction in Huntington's Disease?The Yale journal of biology and medicine · 2019Review
- TBI Rehabilomics Research: Conceptualizing a humoral triad for designing effective rehabilitation interventions.Neuropharmacology · 2019Review
- Inhibition of BDNF signaling in the paraventricular nucleus of the hypothalamus lowers acute stress-induced pressor responses.Journal of neurophysiology · 2018Article
- Lung-injury depresses glutamatergic synaptic transmission in the nucleus tractus solitarii via discrete age-dependent mechanisms in neonatal rats.Brain, behavior, and immunity · 2018Article
- Brain-derived neurotrophic factor acts at neurons of the subfornical organ to influence cardiovascular function.Physiological reports · 2018Article
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
Abstract
Brain-derived neurotrophic factor (BDNF) and its receptor, TrkB, are highly expressed in the nucleus tractus solitarius (nTS), the principal target of cardiovascular primary afferent input to the brainstem. However, little is known about the role of BDNF signaling in nTS in cardiovascular homeostasis. We examined whether BDNF in nTS modulates cardiovascular function in vivo and regulates synaptic and/or neuronal activity in isolated brainstem slices. Microinjection of BDNF into the rat medial nTS (mnTS), a region critical for baroreflex control of sympathetic outflow, produced dose-dependent increases in mean arterial pressure (MAP), heart rate (HR), and lumbar sympathetic nerve activity (LSNA) that were blocked by the tyrosine kinase inhibitor K252a. In contrast, immunoneutralization of endogenous BDNF (anti-BDNF), or microinjection of K252a alone, decreased MAP, HR, and LSNA. The effects of anti-BDNF were abolished by blockade of ionotropic glutamate receptors, indicating a role for glutamate signaling in the response to BDNF. In vitro, BDNF reduced the amplitude of miniature EPSCs as well as solitary tract (TS) evoked EPSC amplitude and action potential discharge (APD) in second-order nTS neurons. BDNF effects on EPSCs were independent of GABAergic signaling and abolished by AMPA receptor blockade. In contrast, K252a increased spontaneous EPSC frequency and TS evoked EPSC amplitude. BDNF also attenuated APD evoked by injection of depolarizing current into second-order neurons, indicating reduced intrinsic neuronal excitability. Our data demonstrate that BDNF signaling in mnTS plays a tonic role in regulating cardiovascular function, likely via modulation of primary afferent glutamatergic excitatory transmission and neural activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.