ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Electrical synaptic input to ganglion cells underlies differences in the output and absolute sensitivity of parallel retinal circuits.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 40 citations in OpenAlex.
- Inhibitory Circuits Can Restore OFF Pathway Responses in Retinal Prostheses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Energetic diversity in retinal ganglion cells is modulated by neuronal activity and correlates with resilience to degeneration.Nature communications · 2026Article
- Divergent mechanisms of neural adaptation and instability in the mammalian retina.Current biology : CB · 2025Article
- Diversity in homeostatic calcium set points predicts retinal ganglion cell survival following optic nerve injury in vivo.Cell reports · 2023Article
- Using optogenetics to dissect rod inputs to OFF ganglion cells in the mouse retina.Frontiers in ophthalmology · 2023Article
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- Type-specific dendritic integration in mouse retinal ganglion cells.Nature communications · 2020Article
- Ocular Hypertension Drives Remodeling of AMPA Receptors in Select Populations of Retinal Ganglion Cells.Frontiers in synaptic neuroscience · 2020Article
- Molecular signatures of retinal ganglion cells revealed through single cell profiling.Scientific reports · 2019Article
- Voltage- and calcium-gated ion channels of neurons in the vertebrate retina.Progress in retinal and eye research · 2019Review
- The dynamic receptive fields of retinal ganglion cells.Progress in retinal and eye research · 2018Review
- Electrical coupling between A17 cells enhances reciprocal inhibitory feedback to rod bipolar cells.Scientific reports · 2018Article
- Electrical synapses convey orientation selectivity in the mouse retina.Nature communications · 2017Article
- Behavioural and physiological limits to vision in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Review
- Processing of single-photon responses in the mammalian On and Off retinal pathways at the sensitivity limit of vision.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2017Article
- Nonlinear Spatiotemporal Integration by Electrical and Chemical Synapses in the Retina.Neuron · 2016Article
- Coincidence detection of single-photon responses in the inner retina at the sensitivity limit of vision.Current biology : CB · 2014Article
- Wiring patterns in the mouse retina: collecting evidence across the connectome, physiology and light microscopy.The Journal of physiology · 2014Review
- Synaptic noise is an information bottleneck in the inner retina during dynamic visual stimulation.The Journal of physiology · 2014Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Parallel circuits throughout the CNS exhibit distinct sensitivities and responses to sensory stimuli. Ambiguities in the source and properties of signals elicited by physiological stimuli, however, frequently obscure the mechanisms underlying these distinctions. We found that differences in the degree to which activity in two classes of Off retinal ganglion cell (RGC) encode information about light stimuli near detection threshold were not due to obvious differences in the cells' intrinsic properties or the chemical synaptic input the cells received; indeed, differences in the cells' light responses were largely insensitive to block of fast ionotropic glutamate receptors. Instead, the distinct responses of the two types of RGCs likely reflect differences in light-evoked electrical synaptic input. These results highlight a surprising strategy by which the retina differentially processes and routes visual information and provide new insight into the circuits that underlie responses to stimuli near detection threshold.
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Registered trials
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