ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Age-dependent homeostatic plasticity of GABAergic signaling in developing retinal networks.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 27 citations in OpenAlex.
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- Carbon nanotube electrodes for retinal implants: A study of structural and functional integration over time.Biomaterials · 2017Article
- A comparison of computational methods for detecting bursts in neuronal spike trains and their application to human stem cell-derived neuronal networks.Journal of neurophysiology · 2016Article
- Monoaminergic tone supports conductance correlations and stabilizes activity features in pattern generating neurons of the lobster, Panulirus interruptus.Frontiers in neural circuits · 2015Article
- Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.The Journal of physiology · 2014Article
- A data repository and analysis framework for spontaneous neural activity recordings in developing retina.GigaScience · 2014Article
- Homeostatic synaptic plasticity in developing spinal networks driven by excitatory GABAergic currents.Neuropharmacology · 2014Review
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- Correlated spontaneous activity persists in adult retina and is suppressed by inhibitory inputs.PloS one · 2013Article
- Refuting the challenges of the developmental shift of polarity of GABA actions: GABA more exciting than ever!Frontiers in cellular neuroscience · 2012Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Developing retinal ganglion cells fire in correlated spontaneous bursts, resulting in propagating waves with robust spatiotemporal features preserved across development and species. Here we investigate the effects of homeostatic adaptation on the circuits controlling retinal waves. Mouse retinal waves were recorded in vitro for up to 35 h with a multielectrode array in presence of the GABA(A) antagonist bicuculline, allowing us to obtain a precise, time-resolved characterization of homeostatic effects in this preparation. Experiments were performed at P4-P6, when GABA(A) signaling is depolarizing in ganglion cells, and at P7-P10, when GABA(A) signaling is hyperpolarizing. At all ages, bicuculline initially increased the wave sizes and other activity metrics. At P5-P6, wave sizes decreased toward control levels within a few hours while firing remained strong, but this ability to compensate disappeared entirely from P7 onwards. This demonstrates that homeostatic control of spontaneous retinal activity maintains specific network dynamic properties in an age-dependent manner, and suggests that the underlying mechanism is linked to GABA(A) signaling.
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Registered trials
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