ArticleJournal of clinical microbiology2011
Clinical and molecular characteristics of invasive and noninvasive skin and soft tissue infections caused by group A Streptococcus.
Article in Journal of clinical microbiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Reconstructive, functional and psychological outcomes in invasive group A streptococcal soft tissue infections: a 10-year retrospective cohort study 2013-2022.BMC infectious diseases · 2026Article
- Molecular Characterization ofMicroorganisms · 2025Article
- Streptococcus pyogenes upregulates arginine catabolism to exert its pathogenesis on the skin surface.Cell reports · 2021Article
- A Review ofPathogens (Basel, Switzerland) · 2021Review
- Article
- Necrotizing Fasciitis by Two Anaerobic Bacteria in an Immunocompetent Patient after Minor Trauma: A Case Report.Case reports in infectious diseases · 2018Article
- Characterization of Streptococcus pyogenes from Animal Clinical Specimens, Spain.Emerging infectious diseases · 2017Article
- Basal insulin therapy is associated with beneficial effects on postoperative infective complications, independently from circulating glucose levels in patients admitted for cardiac surgery.Journal of clinical & translational endocrinology · 2017Article
- Immunization with a streptococcal multiple-epitope recombinant protein protects mice against invasive group A streptococcal infection.PloS one · 2017Article
- Hyaluronan breakdown contributes to immune defense against group A Streptococcus.The Journal of biological chemistry · 2014Article
- Association between polymorphisms in the csrRS two-component regulatory system and invasive group A streptococcal infection.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2014Article
- Epidemiology and molecular characterization of macrolide-resistant Streptococcus pyogenes in Taiwan.Journal of clinical microbiology · 2014Article
- Article
- Emergence of Streptococcus pyogenes emm102 causing toxic shock syndrome in Southern Taiwan during 2005-2012.PloS one · 2013Article
- Insulin modulates the inflammatory granulocyte response to streptococci via phosphatidylinositol 3-kinase.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- Impetigo - review.Anais brasileiros de dermatologiaReview
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The severity of skin and soft tissue infections caused by group A Streptococcus (GAS) is variable, and there are only a limited number of studies evaluating the characteristics of these infections in the literature. From May 2005 to November 2007, 73 patients with skin and soft tissue infections caused by group A Streptococcus were included in this study. Among these patients, 34 (46.6%) had invasive diseases. Diabetes mellitus, alcoholism, and hypertension were the most common underlying disorders. The overall mortality rate was 6.8%, and the elderly were predisposed to invasive infections (P < 0.001). Neutrophil percentages of ≥80, serum creatinine levels of ≥2 mg/dl, and high serum C-reactive protein levels were noted more frequently in patients with invasive infections than in patients with noninvasive infections, as were bacteremia and a high mortality rate. Of the 73 isolates, 93.2%, 97.3%, and 37% exhibited susceptibility to erythromycin, clindamycin, and tetracycline, respectively. The five most prevalent emm types were emm106 (24.7%), emm11 (12.3%), emm102 (9.6%), emm4 (8.2%), and emm12 (8.2%). Compared to other types, the emm106 type was significantly more likely to be associated with invasive diseases (P = 0.012). Dendrogram analysis showed a unique SmaI-digested pulsed-field gel electrophoresis pattern of the emm106 type that was particularly prone to cause invasive skin and soft tissue infections (P < 0.001). The results of this study suggest that isolates with the emm106 gene may be an emerging group A Streptococcus strain that causes invasive skin and soft tissue infections. Further surveillance study to understand the significance of this invasive strain is critical.
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