ArticleNeuro-oncology2011
MRI apparent diffusion coefficient reflects histopathologic subtype, axonal disruption, and tumor fraction in diffuse-type grade II gliomas.
Article in Neuro-oncology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Quantitative magnetic resonance imaging and radiogenomic biomarkers for glioma characterisation: a systematic review.The British journal of radiology · 2018Pooled it
- Hypovascular Cellular Tumor in Primary Central Nervous System Lymphoma is Associated with Treatment Resistance: Tumor Habitat Analysis Using Physiologic MRI.AJNR. American journal of neuroradiology · 2022Article
- Predicting Genotype and Survival in Glioma Using Standard Clinical MR Imaging Apparent Diffusion Coefficient Images: A Pilot Study from The Cancer Genome Atlas.AJNR. American journal of neuroradiology · 2018Article
- Apparent diffusion coefficient for molecular subtyping of non-gadolinium-enhancing WHO grade II/III glioma: volumetric segmentation versus two-dimensional region of interest analysis.European radiology · 2018Article
- Relationship of In Vivo MR Parameters to Histopathological and Molecular Characteristics of Newly Diagnosed, Nonenhancing Lower-Grade Gliomas.Translational oncology · 2018Article
- Whole-Tumor Histogram and Texture Analyses of DTI for Evaluation ofAJNR. American journal of neuroradiology · 2018Article
- Prediction ofAJNR. American journal of neuroradiology · 2018Article
- Biologically aggressive regions within glioblastoma identified by spin-lock contrast T1 relaxation in the rotating frame (T1ρ) MRI.Radiology case reports · 2017Article
- Noninvasive Assessment ofAJNR. American journal of neuroradiology · 2017Article
- Genetically Defined Oligodendroglioma Is Characterized by Indistinct Tumor Borders at MRI.AJNR. American journal of neuroradiology · 2017Article
- Quantitative multi-modal MR imaging as a non-invasive prognostic tool for patients with recurrent low-grade glioma.Journal of neuro-oncology · 2017Article
- The Disruption of Geniculocalcarine Tract in Occipital Neoplasm: A Diffusion Tensor Imaging Study.Radiology research and practice · 2016Article
- Unraveling the multiscale structural organization and connectivity of the human brain: the role of diffusion MRI.Frontiers in neuroanatomy · 2015Review
- Genetics and imaging of oligodendroglial tumors.CNS oncology · 2015Review
- Lower apparent diffusion coefficients indicate distinct prognosis in low-grade and high-grade glioma.Journal of neuro-oncology · 2014Article
- Apparent diffusion coefficient in glioblastoma with PNET-like components, a GBM variant.Journal of neuro-oncology · 2014Article
- Tumor hypoxia and microscopic diffusion capacity in brain tumors: a comparison of (62)Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET/CT and diffusion-weighted MR imaging.European journal of nuclear medicine and molecular imaging · 2014Article
- Can diffusion tensor imaging noninvasively detect IDH1 gene mutations in astrogliomas? A retrospective study of 112 cases.AJNR. American journal of neuroradiology · 2014Article
- Combined diffusion and perfusion MR imaging as biomarkers of prognosis in immunocompetent patients with primary central nervous system lymphoma.AJNR. American journal of neuroradiology · 2013Article
- Regional variation in histopathologic features of tumor specimens from treatment-naive glioblastoma correlates with anatomic and physiologic MR Imaging.Neuro-oncology · 2012Article
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Authors and funding
8 authors at 5 institutions in 1 country.
Funding
Abstract
The apparent diffusion coefficient (ADC) determined from MR diffusion tensor imaging (DTI) has shown promise for distinguishing World Health Organization grade II astrocytoma (AS) from the more prognostically favorable grade II oligodendroglioma (OD). Since mixed oligoastrocytomas (OAs) with codeletions in chromosomes 1p and 19q confer prognoses similar to those of OD, we questioned whether a previously determined ADC-based criterion for distinguishing OD and AS would hold on an independent set of gliomas that included OA with codeleted or intact 1p/19q chromosomes. We also questioned whether the ADC is associated with the tumor microstructure. ADC colormaps generated from presurgical DTI scans were used to guide the collection of biopsies from each tumor. The median normalized ADC distinguished OD from AS with 91% sensitivity and 92% specificity. 1p/19q codeleted OAs were always classified as ODs, while 1p/19q intact OAs were always classified as ASs. There were positive associations between the ADC and both the SMI-31 score of axonal disruption and the fraction of tumor cells in the biopsies. The ADC of OD and 1p/19q codeleted OA was more associated with tumor fraction, while the ADC of AS and 1p/19q intact OA was more associated with SMI-31 score. We conclude that our previously determined threshold median ADC can distinguish grade II OD and AS on a new patient cohort and that the distinctions extend to OA with codeleted and intact 1p/19q chromosomes. Further, the ADC in grade II gliomas is associated with the fraction of tumor cells and degree of axonal disruption in tumor subregions.
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