Trial reportThe Journal of clinical endocrinology and metabolism2011
A randomized pilot study of monthly cycled testosterone replacement or continuous testosterone replacement versus placebo in older men.
Trial report in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Muscular responses to testosterone replacement vary by administration route: a systematic review and meta-analysis.Journal of cachexia, sarcopenia and muscle · 2018Pooled it
- Effects of testosterone on lean mass gain in elderly men: systematic review with meta-analysis of controlled and randomized studies.Age (Dordrecht, Netherlands) · 2015Pooled it
- Cardiovascular risks and elevation of serum DHT vary by route of testosterone administration: a systematic review and meta-analysis.BMC medicine · 2014Pooled it
- Effects of adjunct testosterone on cardiac morphology and function in advanced cancers: an ancillary analysis of a randomized controlled trial.BMC cancer · 2019Trial
- Efficacy of Exercise and Testosterone to Mitigate Atrophic Cardiovascular Remodeling.Medicine and science in sports and exercise · 2018Trial
- Efficacy of Testosterone plus NASA Exercise Countermeasures during Head-Down Bed Rest.Medicine and science in sports and exercise · 2018Trial
- A randomized trial of adjunct testosterone for cancer-related muscle loss in men and women.Journal of cachexia, sarcopenia and muscle · 2018Trial
- Identifying effective and feasible interventions to accelerate functional recovery from hospitalization in older adults: A randomized controlled pilot trial.Contemporary clinical trials · 2016Trial
- Weekly versus monthly testosterone administration on fast and slow skeletal muscle fibers in older adult males.The Journal of clinical endocrinology and metabolism · 2015Trial
- Translational studies in older men using testosterone to treat sarcopenia.Transactions of the American Clinical and Climatological Association · 2014Trial
- Sildenafil increases muscle protein synthesis and reduces muscle fatigue.Clinical and translational science · 2013Trial
- Altered Dynamics in Splanchnic Amino Acid Extraction During Early Sepsis Recovery in Pigs: Whole Body Compared with Interorgan Balance Assessments.The Journal of nutrition · 2026Article
- Musculoskeletal and body composition response to high-dose testosterone with finasteride after chronic incomplete spinal cord injury-a randomized, double-blind, and placebo-controlled pilot study.Frontiers in neurology · 2024Article
- The Roles of Androgens in Humans: Biology, Metabolic Regulation and Health.International journal of molecular sciences · 2022Review
- The Role of Testosterone in the Elderly: What Do We Know?International journal of molecular sciences · 2022Review
- Effects of Testosterone on Serum Concentrations, Fat-free Mass, and Physical Performance by Population: A Meta-analysis.Journal of the Endocrine Society · 2020Article
- Exercise and Testosterone Countermeasures to Mitigate Metabolic Changes during Bed Rest.Life sciences in space research · 2020Article
- Article
- Emerging Evidences in the Long Standing Controversy Regarding Testosterone Replacement Therapy and Cardiovascular Events.The world journal of men's health · 2018Review
- Circulating protein synthesis rates reveal skeletal muscle proteome dynamics.The Journal of clinical investigation · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
contextCycling androgens has been reported by athletes to improve physical performance by enhancing muscle mass and strength, a paradigm that has not been studied, and may have clinical value in older men being treated with testosterone.
objectiveWe investigated the efficacy of a monthly cycled testosterone regimen that uses half the testosterone dose as the current standard of care continuous therapy on body composition and muscle strength in older men. DESIGN, SETTING, AND PATIENTS: Twenty-four community-dwelling older men 70 ± 2 yr of age with total testosterone levels below 500 ng/dl were randomized at the Institute for Translational Sciences-Clinical Research Center into a 5-month double-blind placebo-controlled trial.
interventionSubjects were dosed weekly for 5 months, receiving continuous testosterone (TE, n = 8; 100 mg testosterone enanthate, im injection), monthly cycled testosterone (MO, n = 8; alternating months of testosterone and placebo), or placebo (PL, n = 8).
main outcome measuresMain outcomes included body composition by dual-energy x-ray absorptiometry and upper and lower body muscle strength. Secondary outcomes included body weight, serum hormones, and mixed-muscle protein fractional synthesis rate (FSR).
resultsTotal lean body mass was increased and percent fat was reduced after 5 months in TE and MO (P < 0.05). Upper body muscle strength increased in TE, and lower body muscle strength increased in TE and MO (P < 0.05). FSR increased in TE and MO (P < 0.05) but not in PL.
conclusionsCycled testosterone improved body composition and increased muscle strength compared with placebo and increased FSR similarly to continuous testosterone.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.