Trial reportThe American journal of clinical nutrition2011
Zinc absorption and zinc status are reduced after Roux-en-Y gastric bypass: a randomized study using 2 supplements.
Trial report in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Zinc status following different bariatric procedures: systematic review and meta-analysis.Annals of medicine · 2026Pooled it
- Changes in Nutritional Outcomes After Roux-en-Y Gastric Bypass: A Systematic Review and Meta-Analysis.Obesity surgery · 2024Pooled it
- Zinc Deficiency after Gastric Bypass for Morbid Obesity: a Systematic Review.Obesity surgery · 2017Pooled it
- Trial
- Pain and IBD: The Contributing Role of Diet and Nutrition.Digestive diseases and sciences · 2026Review
- A Comparative Study between Laparoscopic Sleeve Gastrectomy and One Anastomosis Gastric Bypass on Serum Zinc Levels.Obesity surgery · 2026Article
- Symptomatic Chronic Strongyloides Stercoralis Infection after Roux-en-Y Gastric Bypass in an Immunocompetent Patient.European journal of case reports in internal medicine · 2026Article
- Prospective Observational Study on Perioperative Dysgeusia and Trace Metal Elements in Patients Undergoing Pancreatoduodenectomy.Annals of surgery open : perspectives of surgical history, education, and clinical approaches · 2025Article
- Clinical features and genetic analysis of acrodermatitis enteropathica in an ethnic minority infant from Western China: a case report and literature review.Frontiers in medicine · 2025Article
- Recurrent abdominal laparotomy wound infection and dehiscence in a patient with zinc and selenium deficiency associated with Roux-en-Y gastric bypass: Case report and literature review.Journal of family medicine and primary care · 2023Article
- Postoperative Osteoporosis in Subjects with Morbid Obesity Undergoing Bariatric Surgery with Gastric Bypass or Sleeve Gastrectomy.Nutrients · 2023Review
- A Literature Review of Taste Change and Zinc Deficiency After Bariatric Surgery: Could There Be a Causal Link?Obesity surgery · 2023Review
- Serum zinc deficiency in patients after gastrectomy for gastric cancer.International journal of clinical oncology · 2021Article
- The prevalence of zinc deficiency in morbidly obese patients before and after different types of bariatric surgery.BMC endocrine disorders · 2021Article
- Taste alteration after gastrectomy in patients with gastric cancer.Surgery today · 2021Article
- A Prospective Study of Association of Micronutrients Deficiencies during Pregnancy and Neonatal Outcome among Women after Bariatric Surgery.Journal of clinical medicine · 2021Article
- Prevalence of Micronutrient Deficiency after Bariatric Surgery.Obesity facts · 2021Article
- Treatment of COVID-19 Patients Post-Bariatric Surgery: Issues for Consideration.Journal of clinical medicine · 2020Article
- Micronutrient Deficiencies After Roux-en-Y Gastric Bypass: Long-Term Results.Obesity surgery · 2020 · on this mapArticle
- Treatment of Vitamin and Mineral Deficiencies After Biliopancreatic Diversion With or Without Duodenal Switch: a Major Challenge.Obesity surgery · 2018Observational
Corrections and comments
- Commented on by
Authors and funding
15 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMicronutrient deficiencies are common in patients undergoing gastric bypass. The effect of this type of surgery on zinc absorption and zinc status is not well known.
objectiveThe objective was to evaluate the effects of Roux-en-Y gastric bypass (RYGBP) on zinc status and zinc absorption at different stages after surgery. We hypothesized that zinc status would be significantly impaired after surgery and that this impairment would be less severe in subjects receiving increased supplemental zinc. We also hypothesized that zinc absorption would be lower after surgery.
designAnthropometric and body-composition variables and dietary and biochemical indexes of zinc status and zinc absorption were determined in 67 severe and morbidly obese women [mean (±SD) age: 36.9 ± 9.8 y; BMI (in kg/m(2)): 45.2 ± 4.7] who underwent RYGBP. The subjects were randomly assigned to 1 of 2 vitamin-mineral supplementation groups. Measurements were made before and 6, 12, and 18 mo after surgery. Fifty-six subjects completed the 18-mo follow-up.
resultsMean plasma zinc, erythrocyte membrane alkaline phosphatase activity, and the size of the rapidly exchangeable zinc pool decreased after RYGBP. Percentage zinc absorption decreased significantly from 32.3% to 13.6% at 6 mo after RYGBP and to 21% at 18 mo after surgery. No effect of supplement type was observed.
conclusionsZinc status is impaired after RYGBP, despite the finding that dietary plus supplemental zinc doubled recommended zinc intakes in healthy persons. Zinc absorption capacity is significantly reduced soon after RYGBP, with no major changes until 18 mo after surgery.
Indexed as
Identifiers
21865332What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.