Trial reportThe American journal of clinical nutrition2011
Centrally located body fat is associated with lower bone mineral density in older Puerto Rican adults.
Trial report in The American journal of clinical nutrition, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01231958 (The Boston Puerto Rican Health Study), which is not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Boston Puerto Rican Health Study: Center for Population Health and Health Disparities
Who cites it
33 citing papers in PubMed, 69 citations in OpenAlex.
- Impact of high body fat and low muscle mass on bone mineral density in postmenopausal women with type 2 diabetes: A DXA-based cross-sectional study.Aging clinical and experimental research · 2025Article
- Dietary diversity is differentially associated with diet quality across food groups.European journal of nutrition · 2025Article
- Negative correlation between relative fat mass and bone mineral density: NHANES 2011-2018.Frontiers in public health · 2025Article
- Obesity and Skeletal Fragility.The Journal of clinical endocrinology and metabolism · 2024Review
- Gender-specific associations between abdominal adipose mass and bone mineral density in the middle-aged US population.BMC musculoskeletal disorders · 2023Article
- The complex pathophysiology of bone fragility in obesity and type 2 diabetes mellitus: therapeutic targets to promote osteogenesis.Frontiers in endocrinology · 2023Review
- The different correlations between obesity and osteoporosis after adjustment of static mechanical loading from weight and fat free mass.Journal of musculoskeletal & neuronal interactions · 2021Article
- Lifestyle Behavioral Factors and Integrative Successful Aging Among Puerto Ricans Living in the Mainland United States.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Association of some dietary ingredients, vitamin D, estrogen, and obesity polymorphic receptor genes with bone mineral density in a sample of obese Egyptian women.Journal, genetic engineering & biotechnology · 2021Article
- Young cancer survivors have lower bone mineral density compared with healthy controls: a nationwide population-based study in Korea.Scientific reports · 2020Article
- Racial Differences in Dietary Relations to Cognitive Decline and Alzheimer's Disease Risk: Do We Know Enough?Frontiers in human neuroscience · 2020Review
- Is waist circumference a negative predictor of calcaneal bone mineral density in adult Chinese men with normal weight?Annals of translational medicine · 2019Article
- Higher-protein intake and physical activity are associated with healthier body composition and cardiometabolic health in Hispanic adults.Clinical nutrition ESPEN · 2019Article
- Association of body mass index and waist circumference with osteocalcin and C-terminal telopeptide in Iranian elderly: results from a cross-sectional study.Journal of bone and mineral metabolism · 2019Article
- Body composition and circulating estradiol are the main bone density predictors in healthy young and middle-aged men.Journal of endocrinological investigation · 2018Article
- Prevalence of Osteoporosis and Low Bone Mass Among Puerto Rican Older Adults.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Body fat has stronger associations with bone mass density than body mass index in metabolically healthy obesity.PloS one · 2018Article
- Genetic admixture and body composition in Puerto Rican adults from the Boston Puerto Rican Osteoporosis Study.Journal of bone and mineral metabolism · 2017Article
- Combined training (strength plus aerobic) potentiates a reduction in body fat but only functional training reduced low-density lipoprotein cholesterol in postmenopausal women with a similar training load.Journal of exercise rehabilitation · 2017Article
- The beneficial effects of aerobic and concurrent training on metabolic profile and body composition after detraining: a 1-year follow-up in postmenopausal women.European journal of clinical nutrition · 2017Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFat mass is thought to be protective against osteoporosis, primarily because of its weight-bearing effect. Few studies have evaluated the association between abdominal fat mass (AFM) and bone health beyond its weight-bearing effect.
objectiveWe tested the hypothesis that higher body weight-adjusted AFM is associated with poor bone health.
designA cross-sectional study was conducted in 629 Puerto Rican adults aged 47-79 y. Bone mineral density (BMD) of the femoral neck, trochanter, total femur, and lumbar spine (L2-L4) were measured by using dual-energy X-ray absorptiometry (DXA). AFM and total fat mass (TFM) were assessed by using body-composition software from whole-body DXA scans. Osteoporosis and osteopenia were defined as T-scores ≤ -2.5 and -1.0 to -2.5 SD, respectively, at the respective bone site.
resultsAfter confounders were controlled for, body weight-adjusted AFM was inversely associated with BMD at all 4 bone sites in women and at the femoral neck in men. For TFM, small inverse associations were seen at the trochanter and total femur in women. In men, similar associations were seen at the 3 femur sites. In both sexes, the odds for osteoporosis or osteopenia at each of the femoral sites increased by 10-16% for every 100-g increase in body weight-adjusted AFM.
conclusionsHigher AFM was associated with poor bone health in this Puerto Rican sample. Efforts to reduce abdominal obesity will not only reduce the risk of chronic disease but may also improve bone health. This trial is registered at clinicaltrials.gov as NCT01231958.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.