ArticleToxicological sciences : an official journal of the Society of Toxicology2011
Dietary selenium as a modulator of PCB 126-induced hepatotoxicity in male Sprague-Dawley rats.
Article in Toxicological sciences : an official journal of the Society of Toxicology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 34 citations in OpenAlex.
- Metabolic Side Effects from Antipsychotic Treatment with Clozapine Linked to Aryl Hydrocarbon Receptor (AhR) Activation.Biomedicines · 2024Review
- Chronic Aroclor 1260 exposure alters the mouse liver proteome, selenoproteins, and metals in steatotic liver disease.Environmental toxicology and pharmacology · 2024Article
- Selenium, Stroke, and Infection: A Threefold Relationship; Where Do We Stand and Where Do We Go?Nutrients · 2023Review
- PCB126 induced toxic actions on liver energy metabolism is mediated by AhR in rats.Toxicology · 2022Article
- The Aryl hydrocarbon receptor mediates reproductive toxicity of polychlorinated biphenyl congener 126 in rats.Toxicology and applied pharmacology · 2021Article
- PCB126 Inhibits the Activation of AMPK-CREB Signal Transduction Required for Energy Sensing in Liver.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Sources and toxicities of phenolic polychlorinated biphenyls (OH-PCBs).Environmental science and pollution research international · 2018Article
- Spatial distribution of metals within the liver acinus and their perturbation by PCB126.Environmental science and pollution research international · 2018Article
- Identification of lipidomic markers of chronic 3,3',4,4',5-pentachlorobiphenyl (PCB 126) exposure in the male rat liver.Toxicology · 2017Article
- 3,3',4,4',5-Pentachlorobiphenyl (PCB 126) Decreases Hepatic and Systemic Ratios of Epoxide to Diol Metabolites of Unsaturated Fatty Acids in Male Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Assessment of the Mitigative Capacity of Dietary Zinc on PCB126 Hepatotoxicity and the Contribution of Zinc to Toxicity.Chemical research in toxicology · 2016Article
- Dietary Manganese Modulates PCB126 Toxicity, Metal Status, and MnSOD in the Rat.Toxicological sciences : an official journal of the Society of Toxicology · 2016Article
- Progression of micronutrient alteration and hepatotoxicity following acute PCB126 exposure.Toxicology · 2015Article
- Effect of caffeic acid derivatives on polychlorinated biphenyls induced hepatotoxicity in male mice.Journal of biomedical research · 2014Article
- The effects of 3,3',4,4'-tetrabromobiphenyl on rats fed diets containing a constant level of copper and varying levels of molybdenum.Environmental science and pollution research international · 2014Article
- Dietary antioxidants (selenium and N-acetylcysteine) modulate paraoxonase 1 (PON1) in PCB 126-exposed rats.Environmental science and pollution research international · 2014Article
- Sustained expression of CYPs and DNA adduct accumulation with continuous exposure to PCB126 and PCB153 through a new delivery method: Polymeric implants.Toxicology reports · 2014Article
- Does dietary copper supplementation enhance or diminish PCB126 toxicity in the rodent liver?Chemical research in toxicology · 2013Article
- Biological and tumor-promoting effects of dioxin-like and non-dioxin-like polychlorinated biphenyls in mouse liver after single or combined treatment.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- N-acetylcysteine (NAC) diminishes the severity of PCB 126-induced fatty liver in male rodents.Toxicology · 2012Article
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
Homeostasis of selenium (Se), a critical antioxidant incorporated into amino acids and enzymes, is disrupted by exposure to aryl hydrocarbon receptor (AhR) agonists. Here we examined the importance of dietary Se in preventing the toxicity of the most toxic polychlorinated biphenyl congener, 3,3',4,4',5-pentachlorobiphenyl (PCB 126), a potent AhR agonist. Male Sprague-Dawley rats were fed a modified AIN-93 diet with differing dietary Se levels (0.02, 0.2, and 2 ppm). Following 3 weeks of acclimatization, rats from each dietary group were given a single ip injection of corn oil (vehicle), 0.2, 1, or 5 μmol/kg body weight PCB 126, followed 2 weeks later by euthanasia. PCB exposure caused dose-dependent increases in liver weight and at the highest PCB 126 dose decreases in whole body weight gains. Hepatic cytochrome P-450 (CYP1A1) activity was significantly increased even at the lowest dose of PCB 126, indicating potent AhR activation. PCB exposure diminished hepatic Se levels in a dose-dependent manner, and this was accompanied by diminished Se-dependent glutathione peroxidase activity. Both these effects were partially mitigated by Se supplementation. Conversely, thioredoxin (Trx) reductase activity and Trx oxidation state, although significantly diminished in the lowest dietary Se groups, were not affected by PCB exposure. In addition, PCB 126-induced changes in hepatic copper, iron, manganese, and zinc were observed. These results demonstrate that supplemental dietary Se was not able to completely prevent the toxicity caused by PCB 126 but was able to increase moderately the levels of several key antioxidants, thereby maintaining them roughly at normal levels.
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Registered trials
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