Evidence map›Paper›PMID 21865258›Full record

ArticleProceedings. Biological sciences2012

The peopling of Europe and the cautionary tale of Y chromosome lineage R-M269.

George B J Busby, Francesca Brisighelli, Paula Sánchez-Diz, Eva Ramos-Luis, Conrado Martinez-Cadenas, Mark G Thomas, Daniel G Bradley, Leonor Gusmão, Bruce Winney, Walter Bodmer and 18 more

Abstract read
In one paragraph

Article in Proceedings. Biological sciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Phylogeographic review of Y chromosome haplogroups in Europe.International journal of legal medicine · 2021
    Review
  10. Article
  11. Article
  12. The Dutch Y-chromosomal landscape.European journal of human genetics : EJHG · 2020
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. New native South American Y chromosome lineages.Journal of human genetics · 2016
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

George B J BusbyDepartment of Zoology, University of Oxford, Oxford, UK.
Francesca Brisighelli
Paula Sánchez-Diz
Eva Ramos-Luis
Conrado Martinez-Cadenas
Mark G Thomas
Daniel G Bradley
Leonor Gusmão
Bruce Winney
Walter Bodmer
Marielle Vennemann
Valentina Coia
Francesca Scarnicci
Sergio Tofanelli
Giuseppe Vona
Rafal Ploski
Carla Vecchiotti
Tatijana Zemunik
Igor Rudan
Sena Karachanak
Draga Toncheva
Paolo Anagnostou
Gianmarco Ferri
Cesare Rapone
Tor Hervig
Torolf Moen
James F Wilson
Cristian Capelli

Funding

Biotechnology and Biological Sciences Research Council
6 · The paper itself

Abstract

Recently, the debate on the origins of the major European Y chromosome haplogroup R1b1b2-M269 has reignited, and opinion has moved away from Palaeolithic origins to the notion of a younger Neolithic spread of these chromosomes from the Near East. Here, we address this debate by investigating frequency patterns and diversity in the largest collection of R1b1b2-M269 chromosomes yet assembled. Our analysis reveals no geographical trends in diversity, in contradiction to expectation under the Neolithic hypothesis, and suggests an alternative explanation for the apparent cline in diversity recently described. We further investigate the young, STR-based time to the most recent common ancestor estimates proposed so far for R-M269-related lineages and find evidence for an appreciable effect of microsatellite choice on age estimates. As a consequence, the existing data and tools are insufficient to make credible estimates for the age of this haplogroup, and conclusions about the timing of its origin and dispersal should be viewed with a large degree of caution.

Indexed as

Chromosomes, Human, YAsia, WesternEmigration and ImmigrationEuropeGenetics, PopulationGenetic VariationGeographyHaplotypesHumansMaleMiddle EastPolymorphism, Single NucleotideWhite People

Identifiers

PMID21865258
PMCPMC3259916

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.