ArticleJournal of experimental botany2011
Pyrimidine degradation influences germination seedling growth and production of Arabidopsis seeds.
Article in Journal of experimental botany, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 26 citations in OpenAlex.
- Uridine Kinase-like Protein (GhUKL4) Positively Regulates Resistance to Verticillium Wilt in Cotton.Genes · 2025Article
- Spatial specificity of metabolism regulation of abscisic acid-imposed seed germination inhibition in Korean pine (Pinus koraiensis sieb et zucc).Frontiers in plant science · 2024Article
- Pyrimidine catabolism is required to prevent the accumulation of 5-methyluridine in RNA.Nucleic acids research · 2023Article
- New Insights into rice pyrimidine catabolic enzymes.Frontiers in plant science · 2023Article
- HISTONE DEACETYLASE 15 and MOS4-associated complex subunits 3A/3B coregulate intron retention of ABA-responsive genes.Plant physiology · 2022Article
- Metabolome profiling of stratified seeds provides insight into the regulation of dormancy inPlant diversity · 2022Article
- Genetic Architecture and Genome-Wide Adaptive Signatures Underlying Stem Lenticel Traits inInternational journal of molecular sciences · 2021Article
- Nucleoside Metabolism Is Induced in Common Bean During Early Seedling Development.Frontiers in plant science · 2021Article
- Metabolic Labeling of RNAs Uncovers Hidden Features and Dynamics of the Arabidopsis Transcriptome.The Plant cell · 2020Article
- Article
- Nucleotide Metabolism in Plants.Plant physiology · 2020Article
- Pyrimidine Salvage: Physiological Functions and Interaction with Chloroplast Biogenesis.Plant physiology · 2019Article
- UMP Kinase Regulates Chloroplast Development and Cold Response in Rice.International journal of molecular sciences · 2019Article
- Proteomic Analysis of the Function of a Novel Cold-Regulated Multispanning Transmembrane Protein COR413-PM1 inInternational journal of molecular sciences · 2018Article
- Nucleobase and nucleoside transport and integration into plant metabolism.Frontiers in plant science · 2014Review
- Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PYD1 (dihydropyrimidine dehydogenase) initiates the degradation of pyrimidine nucleobases and is located in plastids. In this study, a physiological analysis of PYD1 employing T-DNA knockout mutants and overexpressors was carried out. PYD1 knockout mutants were restricted in degradation of exogenously provided uracil and accumulated high uracil levels in plant organs throughout development, especially in dry seeds. Moreover, PYD1 knockout mutants showed delayed germination which was accompanied by low invertase activity and decreased monosaccharide levels. Abscisic acid (ABA) is an important regulator of seed germination, and ABA-responsive genes were deregulated in PYD1 knockout mutants. Together with an observed increased PYD1 expression in wild-type seedlings upon ABA treatment, an interference of PYD1 with ABA signalling can be assumed. Constitutive PYD1 overexpression mutants showed increased growth and higher seed number compared with wild-type and knockout mutant plants. During senescence PYD1 expression increased to allow uracil catabolism. From this it is concluded that early in development and during seed production PYD1 is needed to balance pyrimidine catabolism versus salvage.
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