ArticleThe Journal of biological chemistry2011
Placenta-specific expression of the interleukin-2 (IL-2) receptor β subunit from an endogenous retroviral promoter.
Article in The Journal of biological chemistry, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- THE1 repeats: Ancient endogenous retroviruses rampaging behind sarcoid myopathy.Journal of human genetics · 2026Review
- Review
- Empowering women's health with miRNA-integrated nanochemical approaches: from reproductive health to cancer care.RSC advances · 2026Review
- Isoform-resolved transcriptome of the human preimplantation embryo.Nature communications · 2023Article
- The successive emergence of ERVL-MaLRs in primates.Virus evolution · 2023Article
- Placental Inflammasome mRNA Levels Differ by Mode of Delivery and Fetal Sex.Frontiers in immunology · 2022Article
- Placental Abnormalities are Associated With Specific Windows of Embryo Culture in a Mouse Model.Frontiers in cell and developmental biology · 2022Article
- Microorganisms as Shapers of Human Civilization, from Pandemics to Even Our Genomes: Villains or Friends? A Historical Approach.Microorganisms · 2021Review
- Analysis of a circRNA-, miRNA-, and mRNA-associated ceRNA network reveals potential biomarkers in preeclampsia a ceRNA network in preeclampsia.Annals of medicine · 2021Article
- Interleukin-15 in Outcomes of Pregnancy.International journal of molecular sciences · 2021Review
- Unique features and emerging in vitro models of human placental development.Reproductive medicine and biology · 2020Review
- The significance of the placental genome and methylome in fetal and maternal health.Human genetics · 2020Review
- Developmental genome-wide DNA methylation asymmetry between mouse placenta and embryo.Epigenetics · 2020Article
- Placental imprinting: Emerging mechanisms and functions.PLoS genetics · 2020Review
- Mechanisms of early placental development in mouse and humans.Nature reviews. Genetics · 2020Review
- Endogenous retroviral insertions drive non-canonical imprinting in extra-embryonic tissues.Genome biology · 2019Article
- Human placental methylome in the interplay of adverse placental health, environmental exposure, and pregnancy outcome.PLoS genetics · 2019Review
- Anthropoid primate-specific retroviral element THE1B controls expression of CRH in placenta and alters gestation length.PLoS biology · 2018Article
- Placental Hypomethylation Is More Pronounced in Genomic Loci Devoid of Retroelements.G3 (Bethesda, Md.) · 2016Article
- The human placental methylome.Cold Spring Harbor perspectives in medicine · 2015Review
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Authors and funding
6 authors.
Funding
Abstract
The long terminal repeat (LTR) sequences of endogenous retroviruses and retroelements contain promoter elements and are known to form chimeric transcripts with nearby cellular genes. Here we show that an LTR of the THE1D retroelement family has been domesticated as an alternative promoter of human IL2RB, the gene encoding the β subunit of the IL-2 receptor. The LTR promoter confers expression specifically in the placental trophoblast as opposed to its native transcription in the hematopoietic system. Rather than sequence-specific determinants, DNA methylation was found to regulate transcription initiation and splicing efficiency in a tissue-specific manner. Furthermore, we detected the cytoplasmic signaling domain of the IL-2Rβ protein in the placenta, suggesting that IL-2Rβ undergoes preferential proteolytic cleavage in this tissue. These findings implicate novel functions for this cytokine receptor subunit in the villous trophoblast and reveal an intriguing example of ancient LTR exaptation to drive tissue-specific gene expression.
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Registered trials
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