ArticlePain2011
Early-life stress produces muscle hyperalgesia and nociceptor sensitization in the adult rat.
Article in Pain, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
56 citing papers in PubMed, 112 citations in OpenAlex.
- Article
- Effects of very early arthritis on pain, behavior, and hippocampal TNF/BDNF in rats.Pediatric research · 2026Article
- Modeling Pain Without Injury: Inherited Rodent Models as Mechanistic Windows into Chronic Pain.Function (Oxford, England) · 2025Review
- Effects of perinatal iron deficiency on spinal dorsal horn circuits.The journal of pain · 2025Article
- Early life adversity increases risk for chronic post-traumatic pain, data from humans and rodents.Pain · 2025Article
- Article
- Adverse Childhood Experiences (ACEs) in Specific Vulnerable Developmental Periods Can Increase the Likelihood of Chronic Pain in Adulthood-Results from a Cross-Sectional Study.Diagnostics (Basel, Switzerland) · 2025Article
- Influence of Early-Life Stress on the Excitability of Dynorphin Neurons in the Adult Mouse Dorsal Horn.The journal of pain · 2024Article
- Early-life stress impairs acquisition and retrieval of fear memories: sex-effects, corticosterone modulation, and partial prevention by targeting glucocorticoid receptors at adolescent age.Neurobiology of stress · 2024Review
- Forced swim stress exacerbates inflammation-induced hyperalgesia and oxidative stress in the rat trigeminal ganglia.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- Effects of Corticosterone on the Excitability of Glutamatergic and GABAergic Neurons of the Adolescent Mouse Superficial Dorsal Horn.Neuroscience · 2023Article
- Current Evidence for Biological Biomarkers and Mechanisms Underlying Acute to Chronic Pain Transition across the Pediatric Age Spectrum.Journal of clinical medicine · 2023Article
- Early-Life Iron Deficiency Persistently Alters Nociception in Developing Mice.The journal of pain · 2023Article
- High-fat/high-sucrose diet worsens metabolic outcomes and widespread hypersensitivity following early-life stress exposure in female mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2023Article
- Integrating the Gut Microbiome and Stress-Diathesis to Explore Post-Trauma Recovery: An Updated Model.Pathogens (Basel, Switzerland) · 2022Article
- Nociceptor Overexpression of NaThe journal of pain · 2021Article
- Pain in the Developing Brain: Early Life Factors Alter Nociception and Neurobiological Function in Adolescent Rats.Cerebral cortex communications · 2021Article
- A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity.Neurobiology of stress · 2020Article
- Article
- Chronic non-inflammatory muscle pain: central and peripheral mediators.Current opinion in physiology · 2019Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Chronic pain in adults has been associated with early-life stress. To examine the pronociceptive effect of early-life stress, we evaluated cutaneous and muscle nociception and activity in muscle nociceptors in an animal model of neonatal stress, limited bedding, in the rat. In this neonatal limited bedding (NLB) model, litters are exposed to limited bedding between postnatal days 2 and 9, and controls to standard bedding. In adult NLB-treated rats, mechanical nociceptive threshold in skeletal muscle was significantly lower (~22%) than in controls. Furthermore, administration of prostaglandin E(2) in skin as well as muscle produced markedly prolonged hyperalgesia, an effect prevented by spinal intrathecal injection of oligodeoxynucleotide antisense to protein kinase Cε (PKCε), a second messenger in nociceptors that has been implicated in the induction and maintenance of chronic pain. In electrophysiological studies, mechanical threshold of muscle nociceptors was reduced by ~31% and conduction velocity significantly increased (~28%). These findings indicate that neonatal stress induces a persistent hyperalgesia and nociceptor sensitization manifest in the adult and that the second messenger PKCε may be a target against which therapies might be directed to treat a chronic pain syndrome that is associated with early-life traumatic stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.