ArticleBiomaterials2011
The pivotal role of fibrocytes and mast cells in mediating fibrotic reactions to biomaterials.
Article in Biomaterials, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 89 citations in OpenAlex.
- Serum tryptase and IgE before and after explantation in women with breast implant illness.JPRAS open · 2026Article
- Evaluation of tissue response of experimental calcium silicate-based endodontic sealers: An in vivo study.European journal of oral sciences · 2026Article
- Mast Cells Control the Bacterial Burden and Grain Formation in Murine Experimental Actinomycetoma Induced byPathogens & immunity · 2026Article
- Periostin mediates collagen production, ECM remodeling and myofibroblast differentiation in breast prosthesis capsule formation.Scientific reports · 2025Article
- Article
- Immunomodulatory contribution of mast cells to the regenerative biomaterial microenvironment.NPJ Regenerative medicine · 2023Article
- Magnesium implant degradation provides immunomodulatory and proangiogenic effects and attenuates peri-implant fibrosis in soft tissues.Bioactive materials · 2023Article
- Innovative biomaterials for the treatment of periodontal disease.Frontiers in dental medicine · 2023Review
- Polysaccharide-Based Membrane Biocompatibility Study ofMaterials (Basel, Switzerland) · 2022Article
- Mast Cell-Biomaterial Interactions and Tissue Repair.Tissue engineering. Part B, Reviews · 2021Review
- Fibrin polymer on the surface of biomaterial implants drives the foreign body reaction.Biomaterials · 2021Article
- Control of innate immune response by biomaterial surface topography, energy, and stiffness.Acta biomaterialia · 2021Review
- Sodium Butyrate Downregulates Implant-Induced Inflammation in Mice.Inflammation · 2020Article
- The Vascular Involvement in Soft Tissue Fibrosis-Lessons Learned from Pathological Scarring.International journal of molecular sciences · 2020Review
- Mast Cell Degranulation and Fibroblast Activation in the Morphine-induced Spinal Mass: Role of Mas-related G Protein-coupled Receptor Signaling.Anesthesiology · 2019Article
- Polymer scaffold architecture is a key determinant in mast cell inflammatory and angiogenic responses.Journal of biomedical materials research. Part A · 2019Article
- Mast cell inhibition as a therapeutic approach in fibrodysplasia ossificans progressiva (FOP).Bone · 2018Article
- Liver tissue engineering: From implantable tissue to whole organ engineering.Hepatology communications · 2018Review
- Depletion of Mast Cells and Macrophages Impairs Heterotopic Ossification in an Acvr1Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2018Article
- Effects of opioid and nonopioid analgesics on canine wheal formation and cultured human mast cell degranulation.Toxicology and applied pharmacology · 2018Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Almost all biomaterial implants are surrounded by a fibrotic capsule, although the mechanism of biomaterial-mediated fibrotic reactions is mostly unclear. To search for the types of cells responsible for triggering the tissue responses, we used poly-L glycolic acid polymers capable of releasing various reagents. We first identified that CD45(+)/Collagen 1(+) fibrocytes are recruited and resided within the fibrotic capsule at the implant interface. Interestingly, we found that the recruitment of fibrocytes and the extent of fibrotic tissue formation (collagen type I production) were substantially enhanced and reduced by the localized release of compound 48/80 and cromolyn, respectively. Since it is well established that compound 48/80 and cromolyn alter mast cell reactions, we hypothesized that mast cells are responsible for triggering fibrocyte recruitment and subsequent fibrotic capsule formation surrounding biomaterial implants. To directly test this hypothesis, similar studies were carried out using mast cell deficient mice, WBB6F1/J-Kit(W)/Kit(W-v)/, and their congenic controls. Indeed, mast cell deficient mice prompted substantially less fibrocyte and myofibroblast responses in comparison to C57 wild type mice controls. Most interestingly, subcutaneous mast cell reconstitution of WBB6F1/J-Kit(W)/Kit(W-v)/J mice almost completely restored the fibrocyte response in comparison to the C57 wild type response. These results indicate that the initial biomaterial interaction resulting in the stimulation of mast cells and degranulation byproducts not only stimulates the inflammatory cascade but significantly alters the downstream fibrocyte response and degree of fibrosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.