Trial reportThe Journal of pediatrics2011
Mortality reduction by heart rate characteristic monitoring in very low birth weight neonates: a randomized trial.
Trial report in The Journal of pediatrics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03004482 (Noninvasive Monitoring and Diagnosis of Physiologic Disturbances in Term and Preterm Newborns Using Video Analysis Techniques), which is not on this map. Cited by 171 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Noninvasive Monitoring and Diagnosis of Physiologic Disturbances in Term and Preterm Newborns Using Video Analysis Techniques
Who cites it
171 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Heart rate variability as a dual-use digital biomarker: integrating clinical, AI, and operational perspectives on human performance and resilience.BMC cardiovascular disorders · 2026Pooled it
- Heart Rate Characteristics Monitoring for Late-Onset Sepsis in Preterm Infants: A Systematic Review.Neonatology · 2023Pooled it
- Severity of hypoxic ischemic encephalopathy and heart rate variability in neonates: a systematic review.BMC pediatrics · 2019Pooled it
- A randomized controlled trial of artificial intelligence-based analytics for clinical deterioration.Scientific reports · 2026Trial
- Impact of race on heart rate characteristics monitoring in very low birth weight infants.Pediatric research · 2023Trial
- Mortality and Neurodevelopmental Outcomes in the Heart Rate Characteristics Monitoring Randomized Controlled Trial.The Journal of pediatrics · 2020Trial
- Multi-complexity measures of heart rate variability and the effect of vasopressor titration: a prospective cohort study of patients with septic shock.BMC infectious diseases · 2016Trial
- Complex signals bioinformatics: evaluation of heart rate characteristics monitoring as a novel risk marker for neonatal sepsis.Journal of clinical monitoring and computing · 2014Trial
- Infection and other clinical correlates of abnormal heart rate characteristics in preterm infants.The Journal of pediatrics · 2014Trial
- Septicemia mortality reduction in neonates in a heart rate characteristics monitoring trial.Pediatric research · 2013Trial
- Abnormal heart rate characteristics before clinical diagnosis of necrotizing enterocolitis.Journal of perinatology : official journal of the California Perinatal Association · 2013Trial
- Dynamic analysis of cardiac rhythms for discriminating atrial fibrillation from lethal ventricular arrhythmias.Circulation. Arrhythmia and electrophysiology · 2013Trial
- Beyond accuracy: translating machine learning risk models into meaningful clinical decision support in neonatal intensive care.Pediatric research · 2026Article
- Temporal trends in heart rate characteristic index preceding necrotizing enterocolitis in preterm infants.Journal of neonatal-perinatal medicine · 2026Article
- Fetal and Neonatal Heart Rate Trends in Preterm Delivery: A Clinical Study from the Week before to the Week after Birth.American journal of perinatology · 2026Article
- Biomarkers for Necrotising Enterocolitis-Are We There Yet?Children (Basel, Switzerland) · 2026Review
- Predicting pulmonary hemorrhage in very low birth weight infants.Pediatric research · 2026Article
- Does "POWS" pack a powerful enough punch to predict pulmonary hemorrhage in preterm infants?Pediatric research · 2026Article
- Cardiorespiratory signatures of necrotizing enterocolitis: a 4-NICU study of very low birth weight infants.Pediatric research · 2026Article
- High-throughput analysis of multimodal monitoring data: the role of machine learning in early warning systems for high-risk neonates.BMJ paediatrics open · 2026Review
111 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
14 authors.
Funding
Abstract
objectiveTo test the hypothesis that heart rate characteristics (HRC) monitoring improves neonatal outcomes. STUDY
designWe conducted a two-group, parallel, individually randomized controlled clinical trial of 3003 very low birth weight infants in 9 neonatal intensive care units. In one group, HRC monitoring was displayed; in the other, it was masked. The primary outcome was number of days alive and ventilator-free in the 120 days after randomization. Secondary outcomes were mortality, number of ventilator days, neonatal intensive care unit stay, and antibiotic use.
resultsThe mortality rate was reduced in infants whose HRC monitoring was displayed, from 10.2% to 8.1% (hazard ratio, 0.78; 95% CI, 0.61-0.99; P = .04; number needed to monitor = 48), and there was a trend toward increased days alive and ventilator-free (95.9 of 120 days compared with 93.6 in control subjects, P = .08). The mortality benefit was concentrated in infants with a birth weight <1000 g (hazard ratio, 0.74; 95% CI, 0.57-0.95; P = .02; number needed to monitor = 23). There were no significant differences in the other outcomes.
conclusionHRC monitoring can reduce the mortality rate in very low birth weight infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.